Role of noncoding RNAs in Trinucleotide repeat neurodegenerative disorders

• Type of Material: Article
• Authors: Huiping Tan, Emory University; Zihui Xu, Emory University; Peng Jin, Emory University
• Language: English
• Date: 2012-06
• Publisher: Elsevier: 12 months
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2012 Elsevier Inc. All rights reserved
• License: Creative Commons Attribution-NonCommerical-NoDerivs 3.0 Unported
• Final Published Version (URL): http://dx.doi.org/10.1016/j.expneurol.2012.01.019
• Title of Journal or Parent Work: Experimental Neurology
• ISSN: 0014-4886
• Volume: 235
• Issue: 2
• Start Page: 469
• End Page: 475
• Grant/Funding Information: H.T. is supported by the China Scholarship Council. P.J. is supported by NIH grants (R01 NS051630 and R21 NS067461).
• Research Categories: Biology, Genetics; Biology, Neuroscience

Abstract

Increasingly complex networks of noncoding RNAs are being found to play important and diverse roles in the regulation of gene expression throughout the genome. Many lines of evidence are linking mutations and dysregulations of noncoding RNAs to a host of human diseases, and noncoding RNAs have been implicated in the molecular pathogenesis of some neurodegenerative disorders. The expansion of trinucleotide repeats is now recognized as a major cause of neurological disorders. Here we will review our current knowledge of the proposed mechanisms behind the involvement of noncoding RNAs in the molecular pathogenesis of neurodegenerative disorders, particularly the sequestration of specific RNA-binding proteins, the regulation of antisense transcripts, and the role of the microRNA pathway in the context of known neurodegenerative disorders caused by the expansion of trinucleotide repeats.