Publication

The impact of early factors on persistent negative symptoms in youth at clinical high risk for psychosis

Downloadable Content

Persistent URL
Last modified
  • 06/25/2025
Type of Material
Authors
    Daniel J Devoe, Hotchkiss Brain InstituteLu Lui, Hotchkiss Brain InstituteTyrone D Cannon, Yale UniversityKristin Suzanne Cadenhead, University of California, San DiegoBarbara A Cornblatt, Zucker Hillside HospitalMatcheri Keshavan, Beth Israel Deaconess Medical CenterTom H McGlashan, Yale School of MedicineDiana O Perkins, The University of North Carolina at Chapel HillLarry J Seidman, Beth Israel Deaconess Medical CenterWilliam S Stone, Beth Israel Deaconess Medical CenterMing T Tsuang, University of California, San DiegoScott W Woods, Yale School of MedicineElaine Walker, Emory UniversityDaniel H Mathalon, University of California, San FranciscoCarrie E Bearden, University of California, Los AngelesJean Addington, Hotchkiss Brain Institute
Language
  • English
Date
  • 2023-01-01
Publisher
  • Frontiers Media S.A
Publication Version
Copyright Statement
  • © 2023 Devoe, Lui, Cannon, Cadenhead, Cornblatt, Keshavan, McGlashan, Perkins, Seidman, Stone, Tsuang, Woods, Walker, Mathalon, Bearden and Addington.
License
Final Published Version (URL)
Title of Journal or Parent Work
Volume
  • 14
Grant/Funding Information
  • This study was supported by the National Institute of Mental Health (grant U01 MH081984 to JA; grants U01 MH081928 and P50 MH080272; Commonwealth of Massachusetts SCDMH82101008006 to LS; grants R01 MH60720, U01 MH082022, and K24 MH76191 to KC; grant U01 MH081902 to TC; P50 MH066286 (Prodromal Core) to CB; grant U01 MH082004 to DP; grant U01 MH081988 to EW; grant U01 MH082022 to SW; and U01 MH081857-05 grant to BC). DD was funded by the Alberta Innovates Graduate Studentship.
Abstract
  • Introduction: Persistent negative symptoms (PNS) are described as continuing moderate negative symptoms. More severe negative symptoms have been associated with poor premorbid functioning in both chronic schizophrenia and first episode psychosis patients. Furthermore, youth at clinical high risk (CHR) for developing psychosis may also present with negative symptoms and poor premorbid functioning. The aim of this current study was to: (1) define the relationship between PNS and premorbid functioning, life events, trauma and bullying, previous cannabis use, and resource utilization, and (2) to examine what explanatory variables best predicted PNS. Method: CHR participants (N = 709) were recruited from the North American Prodrome Longitudinal Study (NAPLS 2). Participants were divided into two groups: those with PNS (n = 67) versus those without PNS (n = 673). A K-means cluster analysis was conducted to distinguish patterns of premorbid functioning across the different developmental stages. The relationships between premorbid adjustment and other variables were examined using independent samples t-tests or chi square for categorical variables. Results: There was significantly more males in the PNS group. Participants with PNS had significantly lower levels of premorbid adjustment in childhood, early adolescence, and late adolescence, compared to CHR participants without PNS. There were no differences between the groups in terms of trauma, bullying, and resource utilization. The non-PNS group had more cannabis use and more desirable and non-desirable life events. Conclusion: In terms of better understanding relationships between early factors and PNS, a prominent factor associated with PNS was premorbid functioning, in particular poor premorbid functioning in later adolescence.
Author Notes
Keywords
Research Categories
  • Health Sciences, Mental Health

Tools

Relations

In Collection:

Items

Thumbnail Title File Description Date Uploaded Visibility Actions
file details Publication File - w7bp5.pdf Primary Content 2025-06-02 Public Download