Regenerative cellular therapies for neurologic diseases

• Type of Material: Article
• Authors: Michael Levy, Johns Hopkins University; Nicholas Boulis, Emory University; Mahendra Rao, National Institutes of Health; Clive N. Svendsen, Cedars-Sinai Medical Center
• Language: English
• Date: 2016-05-01
• Publisher: Elsevier
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2015 Elsevier B.V. All rights reserved.
• License: Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1016/j.brainres.2015.06.053
• Title of Journal or Parent Work: Brain Research
• Volume: 1638
• Start Page: 88
• End Page: 96
• Grant/Funding Information: Dr. Boulis receives research support from NIH, NeuralStem, the Cox Foundation, the Virginia Gentleman’s Foundation, Department of Defense, Taubman Foundation; Dr. Levy receives research support from NIH, Guthy Jackson Charitable Foundation, Acorda, Sanofi, NeuralStem and Genentech
• Keywords: stem cells; meurologic diseases; regeneration
• Research Categories: Biology, Neuroscience; Health Sciences, Medicine and Surgery

Abstract

The promise of stem cell regeneration has been the hope of many neurologic patients with permanent damage to the central nervous system. There are hundreds of stem cell trials worldwide intending to test the regenerative capacity of stem cells in various neurological conditions from Parkinson׳s disease to multiple sclerosis. Although no stem cell therapy is clinically approved for use in any human disease indication, patients are seeking out trials and asking clinicians for guidance. This review summarizes the current state of regenerative stem cell transplantation divided into seven conditions for which trials are currently active: demyelinating diseases/spinal cord injury, amyotrophic lateral sclerosis, stroke, Parkinson׳s disease, Huntington׳s disease, macular degeneration and peripheral nerve diseases.