Inducible nitric oxide synthase is crucial for plasma cell survival

• Type of Material: Article
• Authors: Modesta N Njau, Emory University; Joshy Jacob, Emory University
• Language: English
• Date: 2014-03-01
• Publisher: Nature Research (part of Springer Nature)
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2019 Springer Nature Limited
• Final Published Version (URL): http://dx.doi.org/10.1038/ni.2831
• Title of Journal or Parent Work: Nature Immunology
• ISSN: 1529-2908
• Volume: 15
• Issue: 3
• Start Page: 219
• End Page: 221
• Keywords: APOPTOSIS; Science & Technology; Life Sciences & Biomedicine; Immunology
• Research Categories: Health Sciences, Immunology

Abstract

The viability of long-lived plasma cells is enhanced by the expression of inducible nitric oxide synthase, which relieves endoplasmic reticulum stress by triggering a response dependent on cGMP and protein kinase G.