Current Perspectives on Ophthalmic Manifestations of Childhood Rheumatic Diseases

• Type of Material: Article
• Authors: Neal V. Palejwala, Emory University; Steven Yeh, Emory University; Sheila Angeles-Han, Emory University
• Language: English
• Date: 2013-07
• Publisher: Springer (part of Springer Nature): Springer Open Choice Hybrid Journals
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2013, Springer Science+Business Media New York
• Final Published Version (URL): http://link.springer.com/article/10.1007%2Fs11926-013-0341-3
• Title of Journal or Parent Work: Current Rheumatology Reports
• ISSN: 1523-3774
• Volume: 15
• Issue: 7
• Start Page: 341
• End Page: 341
• Grant/Funding Information: Steven Yeh has received research support via an unrestricted grant from Research to Prevent Blindness (Emory Eye Center), the Knights Templar Educational Foundation of Georgia, and NEI Core Grant for Vision Research (P30 EY 006360); He has also received grant support from Abbott Laboratories and Novartis.; Sheila T. Angeles-Han was supported by the National Eye Institute of the National Institutes of Health under award no. K23 EY021760.
• Keywords: Behcet’s disease; Juvenile spondyloarthropathy; Spondyloarthropathy; Pediatrics; Juvenile idiopathic arthritis; Ophthalmology; Uveitis; Biologic; Eye; Treatment; Systemic lupus erythematosus; HLA-B27; Rheumatic diseases; Childhood
• Research Categories: Health Sciences, Opthamology; Health Sciences, Human Development; Health Sciences, General

Abstract

Inflammatory eye diseases are an important manifestation of many pediatric rheumatologic conditions. Early screening and diagnosis are imperative as these illnesses can not only result in significant visual morbidity but also be an indicator of systemic inflammation. Time to presentation of ocular inflammation varies significantly and can range from many years prior to the onset of systemic symptoms to well after the diagnosis of the rheumatologic disorder. Due to this variability in presentation, careful monitoring by an ophthalmologist is vital to preventing ocular complications and preserving vision. Both local and systemic immunosuppressive medications have been effective in the management of ocular disease. In this review, we will focus on the known ophthalmologic manifestations of common pediatric rheumatologic diseases and discuss recent advances in therapeutic considerations for these conditions.