Is developmental synchrony enabled by CTCF residence time?

• Type of Material: Article
• Authors: Hsiao-Lin V Wang, Emory University; Victor Corces, Emory University
• Language: English
• Date: 2021-09-27
• Publisher: CELL PRESS
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2021 Elsevier Inc.
• License: Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1016/j.devcel.2021.09.003
• Title of Journal or Parent Work: DEVELOPMENTAL CELL
• Volume: 56
• Issue: 18
• Start Page: 2545
• End Page: 2546
• Keywords: Science & Technology; Cell Biology; Developmental Biology; Life Sciences & Biomedicine

Abstract

Depletion of CTCF in cultured cells has minor effects on transcription whereas its mutation leads to embryonic lethality and developmental defects. In a recent issue of Nature Cell Biology, Soochit et al. (2021) show that the residence time of CTCF on DNA may explain its critical role in cell differentiation.