Chemical control of peptide material phase transitions

• Type of Material: Article
• Authors: Junjun Tan, Emory University; Li Zhang, Emory University; Ming-Chien Hsieh, Emory University; Jay T Goodwin, Emory University; Martha A Grover, Georgia Institute of Technology; David Lynn, Emory University
• Language: English
• Date: 2021-02-28
• Publisher: ROYAL SOC CHEMISTRY
• Publication Version: Final Published Version
• Copyright Statement: © The Royal Society of Chemistry
• License: Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported
• Final Published Version (URL): http://dx.doi.org/10.1039/d0sc03666h
• Title of Journal or Parent Work: CHEMICAL SCIENCE
• Volume: 12
• Issue: 8
• Start Page: 3025
• End Page: 3031
• Grant/Funding Information: The research was supported by grants from NSF CHE-1507932 and NSF/DMR-BSF 1610377, and NIH Alzheimer's Disease Research Center: P50AG025688.
• Keywords: Chemistry; Physical Sciences; Chemistry, Multidisciplinary; Science & Technology
• Research Categories: Chemistry, General; Biology, General

Abstract

Progressive solute-rich polymer phase transitions provide pathways for achieving ordered supramolecular assemblies. Intrinsically disordered protein domains specifically regulate information in biological networksviaconformational ordering. Here we consider a molecular tagging strategy to control ordering transitions in polymeric materials and provide a proof-of-principle minimal peptide phase network captured with a dynamic chemical network.