Epidemiological and clinical characteristics of patients with monkeypox in the GeoSentinel Network: a cross-sectional study

• Type of Material: Article
• Authors: Phyllis Kozarsky, Emory University; Kristina Angelo, Emory University; Teresa Smith, Centers for Disease Control and Prevention; Daniel Camprubí-Ferrer, Instituto de Salud Global de Barcelona; Leire Balerdi-Sarasola, Instituto de Salud Global de Barcelona; Marta Díaz Menéndez, Hospital Universitario La Paz; Guillermo Servera-Negre, Hospital Universitario La Paz; Sapha Barkati, McGill Faculty of Medicine and Health Sciences; Alexandre Duvignaud, Groupe Hospitalier Pellegrin; Kristina LB Huber, Ludwig-Maximilians-Universität München; Arpita Chakravarti, Centre Hospitalier de L'Universite de Montreal; Emmanuel Bottieau, Prins Leopold Instituut voor Tropische Geneeskunde; Christina Greenaway, McGill Faculty of Medicine and Health Sciences; Martin P Grobusch, Amsterdam UMC - University of Amsterdam; Diogo Mendes Pedro, Universidade de Lisboa; Hilmir Asgeirsson, Karolinska Universitetssjukhuset; Corneliu P Popescu, Universitatea de Medicina si Farmacie Carol Davila din Bucuresti; Charlotte Martin, Centre Hospitalier Universitaire Saint Pierre, Brussels; Carmelo Licitra, Orlando Health; Albie de Frey, Wits School of Public Health; Eli Schwartz, Chaim Sheba Medical Center Israel; Michael Beadsworth, Liverpool School of Tropical Medicine; Susana Lloveras, Parasitology Laboratory Infectious Diseases Francisco J Muñiz Hospital; Carsten S Larsen, Aarhus Universitetshospital; Sarah Anne J Guagliardo, Centers for Disease Control and Prevention; Florence Whitehill, National Center for Emerging and Zoonotic Infectious Diseases; Ralph Huits, Ospedale Sacro Cuore Don Calabria; Davidson H Hamer, Boston University; Michael Libman, McGill Faculty of Medicine and Health Sciences
• Language: English
• Date: 2023-02-01
• Publisher: Elsevier Ltd.
• Publication Version: Final Published Version
• Copyright Statement: Published by Elsevier Ltd.
• Final Published Version (URL): http://dx.doi.org/10.1016/S1473-3099(22)00651-X
• Title of Journal or Parent Work: The Lancet Infectious Diseases
• Volume: 23
• Issue: 2
• Start Page: 196
• End Page: 206
• Grant/Funding Information: This project was funded through a Cooperative Agreement between the US Centers for Disease Control and Prevention (CDC) and the International Society of Travel Medicine (1 U01CK000632-01-00).
• Keywords: Homosexuality, Male; Exanthema; Young Adult; Male; Female; Middle Aged; Monkeypox; Aged; Sexual and Gender Minorities; Adolescent; Humans; Adult; Smallpox; Cross-Sectional Studies; HIV Infections
• Research Categories: Health Sciences, Medicine and Surgery

Abstract

Background: The early epidemiology of the 2022 monkeypox epidemic in non-endemic countries differs substantially from the epidemiology previously reported from endemic countries. We aimed to describe the epidemiological and clinical characteristics among individuals with confirmed cases of monkeypox infection. Methods: We descriptively analysed data for patients with confirmed monkeypox who were included in the GeoSentinel global clinical-care-based surveillance system between May 1 and July 1 2022, across 71 clinical sites in 29 countries. Data collected included demographics, travel history including mass gathering attendance, smallpox vaccination history, social history, sexual history, monkeypox exposure history, medical history, clinical presentation, physical examination, testing results, treatment, and outcomes. We did descriptive analyses of epidemiology and subanalyses of patients with and without HIV, patients with CD4 counts of less than 500 cells per mm3 or 500 cells per mm3 and higher, patients with one sexual partner or ten or more sexual partners, and patients with or without a previous smallpox vaccination. Findings: 226 cases were reported at 18 sites in 15 countries. Of 211 men for whom data were available, 208 (99%) were gay, bisexual, or men who have sex with men (MSM) with a median age of 37 years (range 18–68; IQR 32–43). Of 209 patients for whom HIV status was known, 92 (44%) men had HIV infection with a median CD4 count of 713 cells per mm3 (range 36–1659; IQR 500–885). Of 219 patients for whom data were available, 216 (99%) reported sexual or close intimate contact in the 21 days before symptom onset; MSM reported a median of three partners (IQR 1–8). Of 195 patients for whom data were available, 78 (40%) reported close contact with someone who had confirmed monkeypox. Overall, 30 (13%) of 226 patients were admitted to hospital; 16 (53%) of whom had severe illness, defined as hospital admission for clinical care rather than infection control. No deaths were reported. Compared with patients without HIV, patients with HIV were more likely to have diarrhoea (p=0·002), perianal rash or lesions (p=0·03), and a higher rash burden (median rash burden score 9 [IQR 6–21] for patients with HIV vs median rash burden score 6 [IQR 3–14] for patients without HIV; p<0·0001), but no differences were identified in the proportion of men who had severe illness by HIV status. Interpretation: Clinical manifestations of monkeypox infection differed by HIV status. Recommendations should be expanded to include pre-exposure monkeypox vaccination of groups at high risk of infection who plan to engage in sexual or close intimate contact. Funding: US Centers for Disease Control and Prevention, International Society of Travel Medicine.