African ancestry gradient is associated with lower systemic f<inf>2</inf>-isoprostane levels

• Type of Material: Article
• Authors: Francis Annor, Georgia State University; Michael Goodman, Emory University; Bharat Thyagarajan, University of Minnesota; Ike Okosun, Georgia State University; Ayo Doumatey, National Institutes of Health; Barbara A. Gower, University of Alabama at Birmingham; Dora Il'yasova, Georgia State University
• Language: English
• Date: 2017-01-31
• Publisher: Hindawi Publishing Corporation
• Publication Version: Final Published Version
• Copyright Statement: © 2017 Francis Annor et al.
• License: Creative Commons Attribution 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1155/2017/8319176
• Title of Journal or Parent Work: Oxidative Medicine and Cellular Longevity
• ISSN: 1942-0900
• Volume: 2017
• Start Page: 8319176
• End Page: 8319176
• Research Categories: Biology, Genetics; Health Sciences, Public Health; Health Sciences, Epidemiology

Abstract

Context. Low levels of systemic F2-isoprostanes (F2-IsoP) increase the risk of diabetes and weight gain and were found in African Americans. Low F2-IsoPs could reflect an unfavorable metabolic characteristic, namely, slow mitochondrial metabolism in individuals with African ancestry. Objective. To examine differences in plasma F2-IsoPs in three groups with a priori different proportion of African ancestry: non-Hispanic Whites (NHWs), US-born African Americans (AAs), and West African immigrants (WAI). Design. Cross-sectional study. Setting. Georgia residents recruited from church communities. Participants. 218 males and females 25-74 years of age, who are self-identified as NHW (n=83), AA (n=56), or WAI (n=79). Main Outcome Measure(s). Plasma F2-IsoPs quantified by gas chromatography-mass spectrometry. Results. After adjustment for age, gender, obesity, and other comorbidities, WAI had lower levels of plasma F2-IsoP than AA (beta-coefficient = -9.8, p<0.001) and AA had lower levels than NHW (beta-coefficient = -30.3, p<0.001). Similarly, among healthy nonobese participants, F2-IsoP levels were lowest among WAI, followed by AA, and the highest levels were among NHW. Conclusion. Plasma F2-IsoPs are inversely associated with African ancestry gradient. Additional studies are required to test whether optimization of systemic F2-IsoP levels can serve as means to improve race-specific lifestyle and pharmacological intervention targeted to obesity prevention and treatment.