Neuropsychiatric symptoms in Alzheimer's disease: Past progress and anticipation of the future

• Type of Material: Article
• Authors: Yonas E. Geda, Mayo Clinic; Lon S. Schneider, University of Southern California; Laura N. Gitlin, Johns Hopkins University; David S. Miller, Bracket; Gwenn S. Smith, Johns Hopkins University; Donald Bliwise, Emory University
• Language: English
• Date: 2013-09-01
• Publisher: Elsevier Science Inc.
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2013 The Alzheimer¢s Association. All rights reserved.
• License: Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1016/j.jalz.2012.12.001
• Title of Journal or Parent Work: Alzheimers and Dementia
• Volume: 9
• Issue: 5
• Start Page: 602
• End Page: 608
• Grant/Funding Information: C.G.L. was supported by the Johns Hopkins Alzheimer’s Disease Research Center (P50-AG005146).; L.N.G. was supported by NIMH grants R24-MH074779, R01-MH079814, and RC1-MH090770-01, and Alzheimer’s Association grant IIRG-07-28686;; Y.E.G. was supported by NIMH grant K01-MH68351, NIA grant U01-AG006786 (the Mayo Clinic Study of Aging), National Center for Research Resources grant RR024150 (Mayo Clinic CTSA [Career Transition Award]), the Robert Wood Johnson Foundation (Harold Amos Scholar), and the European Union Regional Development Fund (Project FNUSA-ICRC: CZ.1.05/1.1.00/02.0123).
• Keywords: Clinical Neurology; RANDOMIZED-TRIAL; Apathy; ASSOCIATION WORKGROUPS; Agitation/aggression; Alzheimer's disease; DEMENTIA; Sleep disorders; DEPRESSION; Mild behavioral impairment; Life Sciences & Biomedicine; Mild cognitive impairment; BEHAVIORAL SYMPTOMS; Science & Technology; MILD COGNITIVE IMPAIRMENT; Neurosciences & Neurology; SCALE; Dementia; Neuropsychiatric symptoms; DIAGNOSTIC GUIDELINES; Delusions; Psychosis; NATIONAL INSTITUTE; Hallucinations; Depression; DOUBLE-BLIND; Behavioral and psychological symptoms of dementia
• Research Categories: Biology, Neuroscience

Abstract

Neuropsychiatric symptoms (NPS) in Alzheimer's disease (AD) are widespread and disabling. This has been known since Dr. Alois Alzheimer's first case, Frau Auguste D., presented with emotional distress and delusions of infidelity/excessive jealousy, followed by cognitive symptoms. Being cognizant of this, in 2010 the Alzheimer's Association convened a research roundtable on the topic of NPS in AD. A major outcome of the roundtable was the founding of a Professional Interest Area (PIA) within the International Society to Advance Alzheimer's Research and Treatment (ISTAART). The NPS-PIA has prepared a series of documents that are intended to summarize the literature and provide more detailed specific recommendations for NPS research. This overview paper is the first of these living documents that will be updated periodically as the science advances. The overview is followed by syndrome-specific synthetic reviews and recommendations prepared by NPS-PIA workgroups on depression, apathy, sleep, agitation, and psychosis.