Variation in Oxytocin Receptor Density in the Nucleus Accumbens has Differential Effects on Affiliative Behaviors in Monogamous and Polygamous Voles

• Type of Material: Article
• Authors: Heather E. Ross, Emory University; Sara M. Freeman, Emory University; Lauren L. Spiegel, Emory University; Xianghui Ren, Harvard Institutes of Medicine and Beth Israel Deaconess Medical Center; Ernest F. Terwilliger, Harvard Institutes of Medicine and Beth Israel Deaconess Medical Center; Larry J. Young, Emory University
• Language: English
• Date: 2009-02-04
• Publisher: Society for Neuroscience
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2009 Society for Neuroscience
• Final Published Version (URL): http://www.jneurosci.org/content/29/5/1312.long
• Title of Journal or Parent Work: Journal of Neuroscience Nursing
• ISSN: 0270-6474
• Volume: 29
• Issue: 5
• Start Page: 1312
• End Page: 1318
• Grant/Funding Information: This study was supported by NIH grants MH064692 to LJY, RR00165 to Yerkes National Primates Research Center, and NSF STC IBN-9876754.
• Keywords: maternal; neuropeptide; autoradiography; virus; cognition; preference
• Research Categories: Biology, Neuroscience; Psychology, Behavioral; Health Sciences, General

Abstract

Oxytocin receptors in the nucleus accumbens have been implicated in the regulation of alloparental behavior and pair bond formation in the socially monogamous prairie vole. Oxytocin receptor density in the nucleus accumbens is positively correlated with alloparenting in juvenile and adult female prairie voles, and oxytocin receptor antagonist infused into the nucleus accumbens blocks this behavior. Furthermore, prairie voles have higher densities of oxytocin receptors in the accumbens than non-monogamous rodent species, and blocking accumbal oxytocin receptors prevents mating-induced partner preference formation. Here we used adeno-associated viral vector gene transfer to examine the functional relationship between accumbal oxytocin receptor density and social behavior in prairie and meadow voles. Adult female prairie voles that over-express oxytocin receptor in the nucleus accumbens displayed accelerated partner preference formation after cohabitation with a male, but did not display enhanced alloparental behavior. However, partner preference was not facilitated in non-monogamous meadow voles by introducing oxytocin receptor into the nucleus accumbens. These data confirm a role for oxytocin receptor in the accumbens in the regulation of partner preferences in female prairie voles, and suggest that oxytocin receptor expression in the accumbens is not sufficient to promote partner preferences in non-monogamous species. These data are the first to demonstrate a direct relationship between oxytocin receptor density in the nucleus accumbens and variation in social attachment behaviors. Thus, individual variation in oxytocin receptor expression in the striatum may contribute to natural diversity in social behaviors.