Intussusception Cases Among Children Admitted to Referral Hospitals in Kenya, 2002-2013: Implications for Monitoring Postlicensure Safety of Rotavirus Vaccines in Africa

• Type of Material: Article
• Authors: Richard Omore, Kenya Medical Research Institute; Francis Osawa, University of Nairobi; Janet Musia, University of Nairobi; Brian Rha, US Centers for Disease Control and Prevention, Atlanta; Amina Ismail, Ministry of Public Health and Sanitation, Kenya; Nicholas Mukaria Kiulia, Institute of Primate Research, Kenya; Fenny Moke, Kenya Medical Research Institute; John Vulule, Kenya Medical Research Institute; Anthony Mungai Wainaina, Kenyatta National Hospital, Kenya; John Tole, Aga Khan University Hospital; Stanley Mugambi Machoki, Aga Khan University Hospital; Pekka J Nuorti, Tampere University; Robert Breiman, Emory University; Umesh D Parashar, US Centers for Disease Control and Prevention; Joel M Montgomery, US Centers for Disease Control and Prevention; Jacqueline E Tate, US Centers for Disease Control and Prevention
• Language: English
• Date: 2016-12-01
• Publisher: OXFORD UNIV PRESS
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © The Author 2015. Published by Oxford University Press on behalf of the Pediatric Infectious Diseases Society. All rights reserved.
• Final Published Version (URL): http://dx.doi.org/10.1093/jpids/piv051
• Title of Journal or Parent Work: JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY
• Volume: 5
• Issue: 4
• Start Page: 465
• End Page: 469
• Grant/Funding Information: This study was funded by the US Agency for International Development and the US Centers for Disease Control and Prevention.
• Keywords: Infectious Diseases; Life Sciences & Biomedicine; Kenya; intussusception; SURVEILLANCE; childhood mortality; MEXICO; risk factors; Science & Technology; Pediatrics

Abstract

To describe the epidemiology of intussusception before introduction of the rotavirus vaccine, we reviewed the records of 280 patients younger than 5 years who were hospitalized in Kenya between 2002 and 2013. The patients who died (18 [6.4%]) had sought care later after symptom onset than the patients who survived (median, 5 vs 3 days, respectively; P = .04). Seeking prompt care may improve therapeutic outcomes.