Publication

Unveiling Tumor Microenvironment Interactions Using Zebrafish Models

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Last modified
  • 06/25/2025
Type of Material
Authors
    Reid Loveless, Augusta UniversityChloe Shay, Emory UniversityYong Teng, Emory University
Language
  • English
Date
  • 2021-01-14
Publisher
  • Frontiers Media SA
Publication Version
Copyright Statement
  • © 2021 Loveless, Shay and Teng.
License
Final Published Version (URL)
Title of Journal or Parent Work
Volume
  • 7
Start Page
  • 611847
End Page
  • 611847
Grant/Funding Information
  • This work was supported in part by NIH grants (R01DE028351 and R03DE028387) to YT.
Abstract
  • The tumor microenvironment (TME) is a rich and active arena that is strategically evolved overtime by tumors to promote their survival and dissemination. Over the years, attention has been focused to characterize and identify the tumor-supporting roles and subsequent targeting potentials of TME components. Nevertheless, recapitulating the human TME has proved inherently challenging, leaving much to be explored. In this regard, in vivo model systems like zebrafish, with its optical clarity, ease of genetic manipulation, and high engraftment, have proven to be indispensable for TME modeling and investigation. In this review, we discuss the recent ways by which zebrafish models have lent their utility to provide new insights into the various cellular and molecular mechanisms driving TME dynamics and tumor support. Specifically, we report on innate immune cell interactions, cytokine signaling, metastatic plasticity, and other processes within the metastatic cascade. In addition, we reflect on the arrival of adult zebrafish models and the potential of patient-derived xenografts.
Author Notes
Keywords
Research Categories
  • Health Sciences, Radiology
  • Health Sciences, Oncology
  • Health Sciences, Rehabilitation and Therapy
  • Health Sciences, Health Care Management

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