The ETS Factor, ETV2: a Master Regulator for Vascular Endothelial Cell Development

• Type of Material: Article
• Authors: Se-Yeong Oh, Emory University; Ju Young Kim, Emory University; Changwon Park, Emory University
• Language: English
• Date: 2015-12-01
• Publisher: Springer Verlag (Germany)
• Publication Version: Final Published Version
• Copyright Statement: © The Korean Society for Molecular and Cellular Biology.
• License: Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported
• Final Published Version (URL): http://dx.doi.org/10.14348/molcells.2015.0331
• Title of Journal or Parent Work: Molecules and Cells
• ISSN: 1016-8478
• Volume: 38
• Issue: 12
• Start Page: 1029
• End Page: 1036
• Grant/Funding Information: This work was supported by the American Heart Association, 11SDG7390074, National Institutes of Health (NIH) R01 HL119291 and the National Center for Advancing Translational Sciences of the NIH under Award Number UL1TR000454.
• Keywords: cell reprogramming; DEFINED FACTORS; Life Sciences & Biomedicine; YOLK-SAC; PROGENITOR SPECIFICATION; ETV2; EMBRYONIC STEM-CELLS; Cell Biology; transcription factors; FORKHEAD TRANSCRIPTION FACTORS; Biochemistry & Molecular Biology; Science & Technology; AORTIC ENDOTHELIUM; CARDIOVASCULAR DEVELOPMENT; GENE-EXPRESSION; DIRECT CONVERSION; HEMATOPOIETIC DEVELOPMENT; endothelial cells
• Research Categories: Biology, Molecular; Biology, Cell

Abstract

Appropriate vessel development and its coordinated function is essential for proper embryogenesis and homeostasis in the adult. Defects in vessels cause birth defects and are an important etiology of diseases such as cardiovascular disease, tumor and diabetes retinopathy. The accumulative data indicate that ETV2, an ETS transcription factor, performs a potent and indispensable function in mediating vessel development. This review discusses the recent progress of the study of ETV2 with special focus on its regulatory mechanisms and cell fate determining role in developing mouse embryos as well as somatic cells.