Lipid concentrations and semen quality: the LIFE study

• Type of Material: Article
• Authors: Enrique F. Schisterman, Eunice Kennedy Shriver National Institute of Child Health and Human Development; Sunni L. Mumford, Eunice Kennedy Shriver National Institute of Child Health and Human Development; Zhen Chen, Eunice Kennedy Shriver National Institute of Child Health and Human Development; Richard W. Browne, State University of New York Bufallo; Dana Boyd Barr, Emory University; Sungduk Kim, Eunice Kennedy Shriver National Institute of Child Health and Human Development; Germaine M. Buck Louis, Eunice Kennedy Shriver National Institute of Child Health and Human Development
• Language: English
• Date: 2014-05-01
• Publisher: Wiley: 12 months
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2014 American Society of Andrology and European Academy of Andrology.
• Final Published Version (URL): http://dx.doi.org/10.1111/j.2047-2927.2014.00198.x
• Title of Journal or Parent Work: Andrology
• ISSN: 2047-2919
• Volume: 2
• Issue: 3
• Start Page: 408
• End Page: 415
• Grant/Funding Information: This work was supported by the Intramural Research Program of the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (contracts #N01-HD-3-3355, N01-HD-3-3356 and N01-HD-3-3358).
• Keywords: HUMAN-SPERM; TIME; epidemiology; semen quality; fecundity; ASSAY; HEALTHY-MEN; FAT; lipoprotein metabolism; FERTILITY; Life Sciences & Biomedicine; Endocrinology & Metabolism; Andrology; CHOLESTEROL; DECLINE; UNITED-STATES; SEMINAL PARAMETERS; Science & Technology
• Research Categories: Health Sciences, Medicine and Surgery; Environmental Sciences; Health Sciences, Public Health

Abstract

The decline in sperm count rates over the last 50 years appears to parallel the rising prevalence of obesity. As lipid levels are strongly associated with obesity, high lipids levels or hyperlipidaemia may thus play an important role in the decline in fertility in addition to other environmental or lifestyle factors. The objective of this population based cohort study was to evaluate the association between men's serum lipid concentrations and semen quality parameters among 501 male partners of couples desiring pregnancy and discontinuing contraception. Each participant provided prospectively up to two semen samples (94% of men provided one or more semen samples, and 77% of men provided a second sample approximately 1 month later). Linear mixed effects models were used to estimate the associations between baseline lipid concentrations and semen quality parameters, adjusted for age, body mass index and race. We found that higher levels of serum total cholesterol, free cholesterol and phospholipids were associated with a significantly lower percentage of spermatozoa with intact acrosome and smaller sperm head area and perimeter. Our results suggest that lipid concentrations may affect semen parameters, specifically sperm head morphology, highlighting the importance of cholesterol and lipid homeostasis for male fecundity.