Publication

Advances in human B cell phenotypic profiling

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Last modified
  • 05/22/2025
Type of Material
Authors
    Denise A. Kaminski, University of RochesterChungwen Wei, Emory UniversityYu Qian, University of Texas Southwestern Medical CenterAlexander F. Rosenberg, University of RochesterIgnacio Sanz, Emory University
Language
  • English
Date
  • 2012-01-01
Publisher
  • Frontiers Media
Publication Version
Copyright Statement
  • © 2012 Kaminski, Wei, Qian, Rosenberg and Sanz.
License
Final Published Version (URL)
Title of Journal or Parent Work
ISSN
  • 1664-3224
Volume
  • 3
Issue
  • OCT
Start Page
  • 302
End Page
  • 302
Grant/Funding Information
  • The University of Rochester Research Subjects Review Board approved all procedures. Supported by NIH U19 AI56390 and R37AI049660 to I. Sanz, and NIH N01 AI40076 to Y. Qian.
Abstract
  • To advance our understanding and treatment of disease, research immunologists have been called-upon to place more centralized emphasis on impactful human studies. Such endeavors will inevitably require large-scale study execution and data management regu- lation ("Big Biology"), necessitating standardized and reliable metrics of immune status and function. A well-known example setting this large-scale effort in-motion is identify- ing correlations between eventual disease outcome and T lymphocyte phenotype in large HIV-patient cohorts using multiparameter flow cytometry. However, infection, immunodefi- ciency, and autoimmunity are also characterized by correlative and functional contributions of B lymphocytes, which to-date have received much less attention in the human Big Biology enterprise. Here, we review progress in human B cell phenotyping, analysis, and bioinformatics tools that constitute valuable resources for the B cell research community to effectively join in this effort.
Author Notes
  • Correspondence: Denise A. Kaminski, The College Writing Program, University of Rochester, PO Box 270058, Rochester, NY 14627, USA. e-mail: dkamins2@z.rochester.edu; Ignacio Sanz, Division of Rheumatology, Lowance Center for Human Immunology, Emory University, 247 Whitehead Biomedical Research Building, 615 Michael Street, Atlanta, GA 30322, USA. e-mail: ignacio.sanz@emory.edu
Keywords
Research Categories
  • Health Sciences, Immunology
  • Health Sciences, General

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