Recovery of fine motor performance after ischemic damage to motor cortex is facilitated by cell therapy in the rhesus monkey

• Type of Material: Article
• Authors: Douglas Rosene, Emory University; Tara L. Moore, Boston University; Monica A. Pessina, Boston University; Seth P. Finklestein, Biotrofix, Inc.; Brian C. Kramer, Janssen Services, LLC Horsham; Ronald J. Killiany, Boston University
• Language: English
• Date: 2013-12-01
• Publisher: Taylor & Francis: STM, Behavioural Science and Public Health Titles
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2013 Informa UK Ltd. All rights reserved: reproduction in whole or part not permitted.
• Final Published Version (URL): http://dx.doi.org/10.3109/08990220.2013.790806
• Title of Journal or Parent Work: Somatosensory and Motor Research
• ISSN: 0899-0220
• Volume: 30
• Issue: 4
• Start Page: 185
• End Page: 196
• Grant/Funding Information: This study was supported by a contract from Advanced Technologies and Regenerative Medicine, LLC (ATRM), RR# 101115-PR, who funded the study and provided CNTO 0007 and a vehicle control.
• Keywords: Motor Cortex; Male; Movement Disorders; Motor Skills; Single-Blind Method; Brain Ischemia; Macaca mulatta; Upper Extremity; Cell- and Tissue-Based Therapy; Functional Laterality; Disease Models, Animal; Hand Strength; Recovery of Function; Animals; Electroencephalography
• Research Categories: Biology, Anatomy; Biology, Animal Physiology; Biology, Neuroscience

Abstract

We investigated the efficacy on recovery of function following controlled cortical ischemia in the monkey of the investigational cell drug product, CNTO 0007. This drug contains a cellular component, human umbilical tissue-derived cells, in a proprietary thaw and inject formulation. Results demonstrate significantly better recovery of motor function in the treatment group with no difference between groups in the volume or surface area of ischemic damage, suggesting that the cells stimulated plasticity.