Publication

Deciphering the glycogenome of schistosomes

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Last modified
  • 02/20/2025
Type of Material
Authors
    Megan L. Mickum, Emory UniversityNina S. Prasanphanich, Emory UniversityJamie Heimburg-Molinaro, Emory UniversityKristoffer E. Leon, Emory UniversityRichard Cummings, Emory University
Language
  • English
Date
  • 2014-08
Publisher
  • Frontiers Research Foundation
Publication Version
Copyright Statement
  • © 2014 Mickum, Prasanphanich, Heimburg-Molinaro, Leon and Cummings. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Final Published Version (URL)
Title of Journal or Parent Work
Volume
  • 5
Issue
  • 262
Start Page
  • 1
End Page
  • 15
Grant/Funding Information
  • The authors acknowledge funding to Richard D. Cummings from NIH NIAID (R01AI101982) and from NIH NIGMS (P41GM103694 and GM098791).
Abstract
  • Schistosoma mansoni and other Schistosoma sp. are multicellular parasitic helminths (worms) that infect humans and mammals worldwide. Infection by these parasites, which results in developmental maturation and sexual differentiation of the worms over a period of 5-6 weeks, induces antibodies to glycan antigens expressed in surface and secreted glycoproteins and glycolipids. There is growing interest in defining these unusual parasite-synthesized glycan antigens and using them to understand immune responses, their roles in immunomodulation, and in using glycan antigens as potential vaccine targets. A key problem in this area, however, has been the lack of information about the enzymes involved in elaborating the complex repertoire of glycans represented by the schistosome glycome. Recent availability of the nuclear genome sequences for Schistosoma sp. has created the opportunity to define the glycogenome, which represents the specific genes and cognate enzymes that generate the glycome. Here we describe the current state of information in regard to the schistosome glycogenome and glycome and highlight the important classes of glycans and glycogenes that may be important in their generation. © 2014 Mickum, Prasanphanich, Heimburg-Molinaro, Leon and Cummings.
Author Notes
  • Richard D. Cummings, Department of Biochemistry, Emory University School of Medicine, 1510 Clifton Rd #4001, Atlanta, GA 30322, USA e-mail: rdcummi@emory.edu
Keywords
Research Categories
  • Chemistry, Biochemistry

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