Hypertension Across a Woman's Life Cycle

• Type of Material: Article
• Authors: Nanette Wenger, Emory University; Anita Arnold, Florida State University; C. Noel Bairey Merz, Cedars Sinai Heart Institute; Rhonda M. Cooper-DeHoff, University of Florida; Keith C. Ferdinand, Tulane University; Jerome L. Fleg, National Heart, Lung, and Blood Institute; Martha Gulati, University of Arizona; Ijeoma Isiadinso, Emory University; Dipti Itchhaporia, Hoag Memorial Hospital Presbyterian Hospital; KellyAnn Light-McGroary, University of Iowa; Kathryn J. Lindley, Washington University; Jennifer H. Mieres, Hofstra Northwell School of Medicine; Mary L. Rosser, Montefiore Medical Center; George R. Saade, University of Texas Medical Branch; Mary Norine Walsh, St. Vincent Heart Center; Carl J. Pepine, University of Florida
• Language: English
• Date: 2018-04-24
• Publisher: Elsevier: 12 months
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2018 American College of Cardiology Foundation
• License: Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1016/j.jacc.2018.02.033
• Title of Journal or Parent Work: Journal of the American College of Cardiology
• ISSN: 0735-1097
• Volume: 71
• Issue: 16
• Start Page: 1797
• End Page: 1813
• Grant/Funding Information: Dr. Cooper-DeHoff has received funding from the National Institutes of Health Pharmacogenomics Research Network grant U01-GM074492.; The authors of this work were supported by contracts from the National Heart, Lung and Blood Institutes, nos. N01-HV-68161, N01-HV-68162, N01-HV-68163, N01-HV-68164, and RO1-HL-073412-01; grants U0164829, U01 HL649141, and U01 HL649241; grants from the Gustavus and Louis Pfeiffer Research Foundation (Danville, New Jersey), The Women's Guild of Cedars-Sinai Medical Center (Los Angeles, California), The Ladies Hospital Aid Society of Western Pennsylvania (Pittsburgh, Pennsylvania), and QMED, Inc (Laurence Harbor, New Jersey); and by the Edythe L. Broad Endowment, the Barbra Streisand Women's Cardiovascular Research and Education Program, the Linda Joy Pollin Women's Heart Health Program, Cedars-Sinai Medical Center (Los Angeles, California), and by the Emory Women's Heart Center, Emory University School of Medicine (Atlanta, Georgia).; No authors received specific funding for this work.; Dr. Pepine has received grant support from the Gatorade Trust through funds distributed by the University of Florida, Department of Medicine; NIH NCATS—University of Florida Clinical and Translational Science UL1TR001427; PCORnet-OneFlorida Clinical Research Consortium, CDRN-1501-26692; and US Department of Defense CDMRP PR161603.
• Keywords: Cardiac & Cardiovascular Systems; ENDOTHELIAL DYSFUNCTION; Science & Technology; JOINT NATIONAL COMMITTEE; RISK-FACTORS; women; BODY-MASS INDEX; pregnancy-related hypertension; Cardiovascular System & Cardiology; prevention; Life Sciences & Biomedicine; CARDIOVASCULAR-DISEASE; CIRCULATING ANGIOGENIC FACTORS; AMBULATORY BLOOD-PRESSURE; HORMONE REPLACEMENT THERAPY; HEART-DISEASE; hypertension; CAUSE-SPECIFIC MORTALITY; race and ethnicity
• Research Categories: Health Sciences, Pharmacology; Health Sciences, Obstetrics and Gynecology; Health Sciences, Medicine and Surgery

Abstract

Hypertension accounts for 1 in 5 deaths among American women, posing a greater burden for women than men, and is among their most important risk factors for death and development of cardiovascular and other diseases. Hypertension affects women in all phases of life, with specific characteristics relating to risk factors and management for primary prevention of hypertension in teenage and young adult women; hypertension in pregnancy; hypertension during use of oral contraceptives and assisted reproductive technologies, lactation, menopause, or hormone replacement; hypertension in elderly women; and issues of race and ethnicity. All are detailed in this review, as is information relative to women in clinical trials of hypertension and medication issues. The overarching message is that effective treatment and control of hypertension improves cardiovascular outcomes. But many knowledge gaps persist, including the contribution of hypertensive disorders of pregnancy to cardiovascular disease risk, the role of hormone replacement, blood pressure targets for elderly women, and so on.