Concentration-time extrapolation of short-term inhalation exposure levels: dimethyl sulfide, a case study using a chemical-specific toxic load exponent

• Type of Material: Article
• Authors: Eugene Demchuk, Agency for Toxic Substances and Disease Registry, Atlanta; Shannon L Ball, Agency for Toxic Substances and Disease Registry, Atlanta; San L Le, Emory University; Andrew J Prussia, Agency for Toxic Substances and Disease Registry, Atlanta
• Language: English
• Date: 2019-01-02
• Publisher: Taylor & Francis
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: Rights managed by Taylor & Francis 2019
• License: Creative Commons Attribution-NonCommercial 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1080/08958378.2018.1551444
• Title of Journal or Parent Work: INHALATION TOXICOLOGY
• Volume: 30
• Issue: 11-12
• Start Page: 448
• End Page: 462
• Grant/Funding Information: S.L.B. and S.L.L. were supported, respectively, by a fellowship from the Oak Ridge Institute for Science and Education and the Rollins Earn and Learn program from the Emory University.
• Keywords: toxic load; ERPG; dimethyl sulfide; inhalation exposure; n-value; TLE; AEGL; volatile organic compound; inhalation; health guidance value

Abstract

Dimethyl sulfide (DMS, CAS 75–18-3) is an industrial chemical. It is both an irritant and neurotoxicant that may be life-threatening because of accidental release. The effects of DMS on public health and associated public health response depend on the exposure concentration and duration. However, currently, public health advisory information exists for only a 1 h exposure duration, developed by the American Industrial Hygiene Association (AIHA). In the present work, the AIHA-reviewed data were computationally extrapolated to other common short-term durations.