Connectivity of the Corticostriatal and Thalamostriatal Systems in Normal and Parkinsonian States: An Update

• Type of Material: Article
• Authors: Anne-Caroline S. Martel, Emory University; Adriana Galvan, Emory University
• Language: English
• Date: 2022-11
• Publisher: Elsevier
• Publication Version: Final Published Version
• Copyright Statement: © 2022 The Authors. Published by Elsevier Inc.
• License: Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International
• Final Published Version (URL): https://doi.org/10.1016%2Fj.nbd.2022.105878
• Title of Journal or Parent Work: Neurobiology of Disease
• Volume: 174
• Start Page: 105878
• Grant/Funding Information: The authors’ research is funded in part by NIH grant P50NS123103, and infrastructure grant to the Emory National Primate Research Center (P51OD011132).
• Keywords: Striatal neurons; Parkinsonism; Striatum; Thalamo; Cortex
• Research Categories: Biology, Neuroscience

Abstract

The striatum receives abundant glutamatergic afferents from the cortex and thalamus. These inputs play a major role in the functions of the striatal neurons in normal conditions, and are significantly altered in pathological states, such as Parkinson’s disease. This review summarizes the current knowledge of the connectivity of the corticostriatal and thalamostriatal pathways, with emphasis on the most recent advances in the field. We also discuss novel findings regarding structural changes in cortico- and thalamostriatal connections that occur in these connections as a consequence of striatal loss of dopamine in parkinsonism.