Publication

The Association Between Polymorphisms in Cell-Cycle Genes and Mitochondrial DNA Copy Number in Coke Oven Workers

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Last modified
  • 06/17/2025
Type of Material
Authors
    Yuping Wang, Zhengzhou UniversityJiebing Tan, Zhengzhou UniversityWei Wang, Zhengzhou UniversityXiaoran Duan, First Affiliated Hospital of Zhengzhou UniversityBrooke Lappe, Emory UniversityLiuhua Shi, Emory UniversityYongli Yang, Zhengzhou UniversityXuezhong Shi, Zhengzhou University
Language
  • English
Date
  • 2022-07-05
Publisher
  • Frontiers Media S.A.
Publication Version
Copyright Statement
  • © 2022 Wang, Tan, Wang, Duan, Lappe, Shi, Yang and Shi.
License
Final Published Version (URL)
Title of Journal or Parent Work
Volume
  • 10
Start Page
  • 904856
End Page
  • 904856
Grant/Funding Information
  • The work was supported by the National Science Foundation of China (NSFC81872597 and 81001239) and the HERCULES Exposome Research Centre (P30ES019776).
Abstract
  • The mitochondrial DNA (mtDNA) copy number is a vital component in maintaining normal mitochondrial function. It is affected by environmental and occupational exposures, as well as polymorphisms in nuclear genes. Nonetheless, the specific roles of polymorphisms in cell-cycle genes and mtDNA copy number are still unknown. This study enrolled a sample of 544 coke oven workers and 238 non-exposed controls so as to assess the effect of exposure of coke oven emissions (COEs) and polymorphisms in cell-cycle genes on the mtDNA copy number. We found that the mtDNA copy number in the exposed group (0.60 ± 0.29) was significantly lower than that in the control group (1.03 ± 0.31) (t =18.931, P < 0.001). The analysis of covariance showed that both the rs1801270 (CA+CC) and the rs1059234 (CT+CC) in p21 gene were associated with lower mtDNA copy number in the exposed group (P = 0.001). Generalized linear models indicated COEs-exposure (β = −0.432, P < 0.001) and rs1059234 (CT+CC) in p21 gene (β = −0.060, P = 0.024) were the factors in mtDNA copy number reduction. In conclusion, this study suggests that the decrease of the mtDNA copy number is associated with COEs-exposure and the rs1059234 (CT+CC) in the p21 gene.
Author Notes
Keywords
Research Categories
  • Environmental Sciences
  • Biology, Biostatistics
  • Health Sciences, Epidemiology

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