Flavonoids: promising natural compounds against viral infections

• Type of Material: Article
• Authors: Hovakim Zakaryan, Institute of Molecular Biology; Erik Arabyan, Institute of Molecular Biology; Adrian Oo, Universiti Malaya; Keivan Zandi, Emory University
• Language: English
• Date: 2017-09-01
• Publisher: SPRINGER WIEN
• Publication Version: Final Published Version
• Copyright Statement: © 2017, Springer-Verlag Wien.
• Final Published Version (URL): http://dx.doi.org/10.1007/s00705-017-3417-y
• Title of Journal or Parent Work: ARCHIVES OF VIROLOGY
• Volume: 162
• Issue: 9
• Start Page: 2539
• End Page: 2551
• Grant/Funding Information: This study is supported by the RA MES State Committee of Science, in the frames of the research projects 15RF-081 and 16YR-1F064. All authors declare that they have no conflict of interest. This article does not contain any studies with human participants or animals performed by any of the authors.
• Keywords: GREEN TEA; Life Sciences & Biomedicine; Virology; ENTEROVIRUS 71; ANTIVIRAL ACTIVITY; HEPATITIS-C VIRUS; Science & Technology; ANTI-CHIKUNGUNYA ACTIVITY; REVERSE-TRANSCRIPTASE; EPIGALLOCATECHIN GALLATE; INFLUENZA-VIRUS; IN-VITRO; B-VIRUS
• Research Categories: Biology, Virology; Health Sciences, Immunology

Abstract

Flavonoids are widely distributed as secondary metabolites produced by plants and play important roles in plant physiology, having a variety of potential biological benefits such as antioxidant, anti-inflammatory, anticancer, antibacterial, antifungal and antiviral activity. Different flavonoids have been investigated for their potential antiviral activities and several of them exhibited significant antiviral properties in in vitro and even in vivo studies. This review summarizes the evidence for antiviral activity of different flavonoids, highlighting, where investigated, the cellular and molecular mechanisms of action on viruses. We also present future perspectives on therapeutic applications of flavonoids against viral infections.