Comparison of smoking-related DNA methylation between newborns from prenatal exposure and adults from personal smoking

• Type of Material: Article
• Authors: Sinjini Sikdar, National Institutes of Health; Roby Joehanes, Harvard Medical School; Bonnie R. Joubert, National Institutes of Health; Cheng-Jian Xu, University of Groningen; Marta Vives-Usano, Barcelona Institute for Global Health; Faisal I. Rezwan, University of Southampton; Janine F. Felix, Erasmus MC; Karen Conneely, Emory University; Isabelle Romieu, Emory University; Stephanie J. London, National Institutes of Health
• Language: English
• Date: 2019-10-01
• Publisher: FUTURE MEDICINE LTD
• Publication Version: Final Published Version
• Copyright Statement: © 2019 Sinjini Sikdar.
• License: Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.2217/epi-2019-0066
• Title of Journal or Parent Work: EPIGENOMICS
• Volume: 11
• Issue: 13
• Start Page: 1487
• End Page: 1500
• Grant/Funding Information: Funded by the Intramural Research Program of National Institutes of Health (National Institute of Environmental Health Sciences ZO1 ES49019) in addition to funding for individual authors and cohorts listed in the Supplementary Acknowledgements and Funding document.; The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.
• Keywords: MATERNAL SMOKING; Science & Technology; PREGNANCY; KEGG; CYP2A6; 1A2; maternal exposure; Life Sciences & Biomedicine; infant; PACKAGE; epigenetics; methylation; cigarette smoking; NICOTINE; Genetics & Heredity; EXPRESSION
• Research Categories: Health Sciences, Public Health; Health Sciences, Obstetrics and Gynecology; Biology, Genetics

Abstract

Aim: Cigarette smoking influences DNA methylation genome wide, in newborns from pregnancy exposure and in adults from personal smoking. Whether a unique methylation signature exists for in utero exposure in newborns is unknown. Materials & methods: We separately meta-analyzed newborn blood DNA methylation (assessed using Illumina450k Beadchip), in relation to sustained maternal smoking during pregnancy (9 cohorts, 5648 newborns, 897 exposed) and adult blood methylation and personal smoking (16 cohorts, 15907 participants, 2433 current smokers). Results & conclusion: Comparing meta-analyses, we identified numerous signatures specific to newborns along with many shared between newborns and adults. Unique smoking-associated genes in newborns were enriched in xenobiotic metabolism pathways. Our findings may provide insights into specific health impacts of prenatal exposure on offspring.