Drown Them in Their Own Garbage: a New Strategy To Reverse Polymyxin Resistance?

• Type of Material: Article
• Authors: Kerrie L May, Emory University
• Language: English
• Date: 2022-02-01
• Publisher: American Society for Microbiology
• Publication Version: Final Published Version
• Copyright Statement: © 2022 American Society for Microbiology. All Rights Reserved.
• Final Published Version (URL): http://dx.doi.org/10.1128/jb.00574-21
• Title of Journal or Parent Work: JOURNAL OF BACTERIOLOGY
• Volume: 204
• Issue: 2
• Grant/Funding Information: This work was funded by National Institute of General Medical Sciences grant R35 GM133509.
• Keywords: mobile colistin resistance; membranes; Gram-negative bacteria; lipopolysaccharide; polymyxins; antibiotic resistance

Abstract

Purcell and colleagues offer new insights into a major mechanism of polymyxin resistance in Gram-negative bacteria (A. B. Purcell, B. J. Voss, and M. S. Trent, J Bacteriol 204:e00498-21, 2022, https://doi.org/10.1128/JB.00498-21). Inactivating a single lipid recycling enzyme causes accumulation of waste lipid by-products that inhibit a key factor responsible for polymyxin resistance.