Publication

Lower Affinity T Cells are Critical Components and Active Participants of the Immune Response

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Last modified
  • 02/20/2025
Type of Material
Authors
    Ryan J. Martinez, Emory UniversityRakieb Andargachew, Emory UniversityHunter A. Martinez, Emory UniversityBrian Evavold, Emory University
Language
  • English
Date
  • 2015-09-10
Publisher
  • Frontiers Media
Publication Version
Copyright Statement
  • © 2015 Martinez and Evavold.
Final Published Version (URL)
Title of Journal or Parent Work
ISSN
  • 1664-3224
Volume
  • 6
Grant/Funding Information
  • This work was supported by NIH grant T32 AI007610, RO1 NS071518, and RO1 AI110113 to BE and F31 NS086130 to RM.
Supplemental Material (URL)
Abstract
  • Kinetic and biophysical parameters of T cell receptor (TCR) and peptide:MHC (pMHC) interaction define intrinsic factors required for T cell activation and differentiation. Although receptor ligand kinetics are somewhat cumbersome to assess experimentally, TCR:pMHC affinity has been shown to predict peripheral T cell functionality and potential for forming memory. Multimeric forms of pMHC monomers have often been used to provide an indirect readout of higher affinity T cells due to their availability and ease of use while allowing simultaneous definition of other functional and phenotypic characteristics. However, multimeric pMHC reagents have introduced a bias that underestimates the lower affinity components contained in the highly diverse TCR repertoires of all polyclonal T cell responses. Advances in the identification of lower affinity cells have led to the examination of these cells and their contribution to the immune response. In this review, we discuss the identification of high- vs. low-affinity T cells as well as their attributed signaling and functional differences. Lastly, mechanisms are discussed that maintain a diverse range of low- and high-affinity T cells.
Author Notes
Keywords
Research Categories
  • Health Sciences, Immunology
  • Biology, General

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