Current and Future Clinical Applications for Optical Imaging of Cancer: From Intraoperative Surgical Guidance to Cancer Screening

• Type of Material: Article
• Authors: Constantinos G Hadjipanayis, Emory University; Huabei Jiang, University of Florida; David W. Roberts, Dartmouth-Hitchcock Medical Center; Lily Yang, Emory University
• Language: English
• Date: 2011-02
• Publisher: Elsevier: 12 months
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2011 Elsevier Inc. All rights reserved.
• Final Published Version (URL): http://dx.doi.org/10.1053/j.seminoncol.2010.11.008
• Title of Journal or Parent Work: Seminars in Oncology
• ISSN: 0093-7754
• Volume: 38
• Issue: 1
• Start Page: 109
• End Page: 118
• Grant/Funding Information: National Institute of Neurological Disorders and Stroke : NINDS
• Keywords: Breast Cancer; Glioblastoma; Cancer; Nanoparticles; Bladder Cancer; Near Infrared; Optical Imaging
• Research Categories: Health Sciences, Oncology

Abstract

Optical imaging is an inexpensive, fast, and sensitive imaging approach for the non-invasive detection of human cancers in locations that are accessible by an optical imaging device. Light is used to probe cellular and molecular function in the context of cancer in the living body. Recent advances in the development of optical instrumentation make it possible to detect optical signals produced at a tissue depth of several centimeters. The optical signals can be endogenous contrasts that capture the heterogeneity and biological status of different tissues including tumors, or extrinsic optical contrasts that selectively accumulate in tumors to be imaged after local or systemic delivery. The use of optical imaging is now being applied in the clinic and operating room for the localization and resection of malignant tumors in addition to screening for cancer.