Spontaneous Pituitary Adenomas in Squirrel Monkeys (Saimiri sciureus)

• Type of Material: Article
• Authors: Gregory J. Daggett Jr, University of Wisconsin; Jennifer Wood, Emory University; Sanjeev Gumber, Emory University; Christopher Pinelli, Emory University
• Language: English
• Date: 2020-02-01
• Publisher: American Association for Laboratory Animal Science
• Publication Version: Final Published Version
• Copyright Statement: © American Association for Laboratory Animal Science
• Final Published Version (URL): http://dx.doi.org/10.30802/AALAS-CM-18-000137
• Title of Journal or Parent Work: COMPARATIVE MEDICINE
• Volume: 70
• Issue: 1
• Start Page: 83
• End Page: 86
• Grant/Funding Information: The Yerkes National Primate Center is supported by the NIH, Office of Research Infrastructure Programs, Office of the Director (P51OD011132).
• Keywords: subclinical neoplasm; pituitary tumor; immunohistochemical identification; spontaneous pituitary tumors; thyroid-stimulating hormone; antemortem prevalence; dominant cell type; CNS neoplasm; hormonal cell products
• Research Categories: Health Sciences, Immunology; Biology, Cell; Health Sciences, Oncology

Abstract

On postmortem examination, 2 geriatric captive male squirrel monkeys (Saimiri sciureus) were found to have pituitary masses that were unassociated with previous experimental manipulation. Both animals were euthanized due to apparently unrelated clinical reasons. Histopathology and immunohistochemical staining classified these tumors as thyrotrophic and corticotrophic pituitary adenomas. These cases represent the first reports of this tumor type in squirrel monkeys.