The role of deleterious mutations in influenza’s adaptive (antigenic) evolution

• Type of Material: Presentation
• Authors: Katharina V. Koelle, Emory University; David Rasmussen, Duke University
• Language: English
• Date: 2014-08-19
• Publisher: Emory University Libraries
• Copyright Statement: Duke University work-for-hire
• Final Published Version (URL): https://www.on.kitp.ucsb.edu/download/superbugs14/koelle/pdf/Koelle_Superbugs14_KITP.pdf
• Grant/Funding Information: James S. McDonnell Foundation
• Keywords: influenza; genetic diversity; segmented RNA; viral population; seasonal flu; antigenic evolution
• Research Categories: Biology, Virology; Biology, Genetics

Abstract

The virus: Influenza A/H3N2 • Seasonal flu in humans caused by: influenza A/H3N2, A/H1N1, B • Present in humans since 1968 • Segmented RNA virus (8 segments) • Hemagglutinin HA = ‘H’ of H3N2 • Importance of HA for antigenic evolution • Rapid turnover of viral population • Low genetic diversity at any point in time