From Vaccines to Memory and Back

• Type of Material: Article
• Authors: Federica Sallusto, Institute for Research in Biomedicine; Antonio Lanzavecchia, Institute for Research in Biomedicine; Koichi Araki, Emory University; Rafi Ahmed, Emory University
• Language: English
• Date: 2010-10-29
• Publisher: Elsevier (Cell Press)
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2010 Elsevier Inc.
• License: Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1016/j.immuni.2010.10.008
• Title of Journal or Parent Work: Immunity
• ISSN: 1074-7613
• Volume: 33
• Issue: 4
• Start Page: 451
• End Page: 463
• Keywords: Life Sciences & Biomedicine; Science & Technology; Immunology; CHRONIC VIRAL-INFECTION; T-CELL MEMORY; DENDRITIC CELLS; HUMAN MONOCLONAL-ANTIBODIES; BONE-MARROW; B-CELLS; DENGUE VIRUS; HYPER-IGE SYNDROME; IMMUNE-RESPONSE; PLASMA-CELLS
• Research Categories: Biology, Microbiology; Health Sciences, Immunology

Abstract

Vaccines work by eliciting an immune response and consequent immunological memory that mediates protection from infection or disease. Recently, new methods have been developed to dissect the immune response in experimental animals and humans, which have led to increased understanding of the molecular mechanisms that control differentiation and maintenance of memory T and B cells. In this review we will provide an overview of the cellular organization of immune memory and underline some of the outstanding questions on immunological memory and how they pertain to vaccination strategies. Finally we will discuss how we can learn about antigen design from the interrogation of our memory T and B cells-a journey from vaccines to memory and back.