Spinal cord ependymoma: a review of the literature and case series of ten patients

• Type of Material: Article
• Authors: Emma Celano, Emory University School of Medicine; Arsalaam Salehani, Emory University School of Medicine; James G. Malcolm, Emory University School of Medicine; Erik Reinertsen, Emory University School of Medicine; Constantinos G. Hadjipanayis, Icahn School of Medicine at Mount Sinai
• Language: English
• Date: 2016-07-29
• Publisher: Springer Nature
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2021 Springer Nature Switzerland AG
• Final Published Version (URL): http://dx.doi.org/10.1007/s11060-016-2135-8
• Title of Journal or Parent Work: Journal of Neuro-Oncology
• Volume: 128
• Issue: 3
• Start Page: 377
• End Page: 386
• Keywords: ependymomaa
• Research Categories: Biology, Neuroscience

Abstract

Spinal cord ependymoma (SCE) is a rare tumor that is most commonly low-grade. Complete surgical resection has been established as first-line treatment and can be curative. However, SCEs tend to recur when complete tumor resection is not possible. Evidence supporting the use of adjuvant radiation and chemotherapy is not definitive. We review the most recent literature on SCE covering a comprehensive range of topics spanning the biology, presentation, clinical management, and outcomes. In addition, we present a case series of ten SCE patients with the goal of contributing to existing knowledge of this rare disease.