NADPH Oxidases and Angiotensin II Receptor Signaling

• Type of Material: Article
• Authors: Abel Martin Garrido, Emory University; Kathy Griendling, Emory University
• Language: English
• Date: 2009-04-29
• Publisher: Elsevier: 12 months
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2008 Elsevier Ireland Ltd. All rights reserved.
• License: Creative Commons Attribution-NonCommerical-NoDerivs 3.0 Unported
• Final Published Version (URL): http://dx.doi.org/10.1016/j.mce.2008.11.003
• Title of Journal or Parent Work: Molecular and Cellular Endocrinology
• ISSN: 0303-7207
• Volume: 302
• Issue: 2
• Start Page: 148
• End Page: 158
• Grant/Funding Information: This work was supported by NIH grants HL38206, HL075209, HL058000, and HL05863.
• Keywords: vascular; reactive oxygen species; brain; NADPH oxidases; kidney; Angiotensin II
• Research Categories: Biology, Molecular; Biology, Cell

Abstract

Over the last decade many studies have demonstrated the importance of reactive oxygen species (ROS) production by NADPH oxidases in angiotensin II (Ang II) signaling, as well as a role for ROS in the development of different diseases in which Ang II is a central component. In this review, we summarize the mechanism of activation of NADPH oxidases by Ang II and describe the molecular targets of ROS in Ang II signaling in the vasculature, kidney and brain. We also discuss the effects of genetic manipulation of NADPH oxidase function on the physiology and pathophysiology of the renin angiotensin system.