Publication

Editorial: The molecular mechanisms of metastasis and therapeutic resistance in breast cancer

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Last modified
  • 06/25/2025
Type of Material
Authors
    Yuanke Liang, The First Affiliated Hospital of Shantou University Medical CollegeDonghong Zhang, Emory UniversityGary M Tse, Prince of Wales Hospital Hong KongHaoyu Lin, The First Affiliated Hospital of Shantou University Medical CollegeFrank Kruyt, Universitair Medisch Centrum Groningen
Language
  • English
Date
  • 2023-01-01
Publisher
  • Frontiers
Publication Version
Copyright Statement
  • © 2023 Liang, Zhang, Tse, Lin and Kruyt
License
Final Published Version (URL)
Title of Journal or Parent Work
Volume
  • 13
Start Page
  • 1194858
End Page
  • 1194858
Abstract
  • Breast cancer (BC) is the leading cause of cancer-related death among women worldwide (1). The majority of BC-related deaths result from disease recurrence and metastasis, usually related to genetic alterations, epigenetic modification, and cellular plasticity, including cancer stem cells and epithelial-to-mesenchymal transition (EMT) (2–4). This is also a consequence of both intrinsic or acquired resistance to various therapies, such as chemotherapy, endocrine therapy, anti-HER-2 therapy, radiotherapy, and even immunotherapy, which remains a major problem and the most important reason for BC treatment failure (5, 6). Thus, a deeper understanding of the molecular mechanisms of tumor metastasis and therapeutic resistance in BC is needed.
Author Notes
Keywords
Research Categories
  • Health Sciences, Pharmacology
  • Health Sciences, Pathology

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