Meeting Report: Spontaneous Lesions and Diseases in Wild, Captive-Bred, and Zoo-Housed Nonhuman Primates and in Nonhuman Primate Species Used in Drug Safety Studies

• Type of Material: Article
• Authors: VG Sasseville, Novartis Institutes for BioMedical Research, Inc.; KG Mansfield, Novartis Institutes for BioMedical Research, Inc.; JL Mankowski, The Johns Hopkins School of Medicine; C Tremblay, Charles River Laboratories, Inc.; KA Terio, University of Illinois; K Mätz-Rensing, Deutsches Primatenzentrum; E Gruber-Dujardin, Deutsches Primatenzentrum; MA Delaney, University of Illinois; LD Schmidt, Wake Forest University School of Medicine; D Liu, Tulane National Primate Research Center; JE Markovits, Novartis Institutes for BioMedical Research, Inc.; M Owston, Southwest National Primate Research Center; C Harbison, New England Regional Primate Research Center; S Shanmukhappa, New England Regional Primate Research Center; AD Miller, New England Regional Primate Research Center; S Kaliyaperumal, New England Regional Primate Research Center; BT Assaf, New England Regional Primate Research Center; L Kattenhorn, New England Regional Primate Research Center; S. Cummings Macri, New England Regional Primate Research Center; Prachi Sharma, Emory University
• Language: English
• Date: 2012-11-16
• Publisher: SAGE Publications (UK and US)
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © The Author(s) 2012.
• Final Published Version (URL): http://dx.doi.org/10.1177/0300985812461655
• Title of Journal or Parent Work: Veterinary Pathology
• ISSN: 0300-9858
• Volume: 49
• Issue: 6
• Start Page: 1057
• End Page: 1069
• Grant/Funding Information: The following authors disclosed receipt of the following financial support for research, authorship, and/or publication of this article: National Center for Research Resources (NCRR) P51RR165 and is currently supported by the Office of Research Infrastructure Programs (ORIP) of the National Institutes of Health (NIH) through Grant Number OD P51OD11132 (PS, CLC); NIH grants NCRR RR007002 (RJM); P51 RR013986 (MO); NCRR/ORIP RR07000 and RR00168 (SCM, LK, BTA, SK, AM, SS, CH); P51 RR000164 (DL); P51 RR000167 (HAS); P40 OD010965-08 (JMC, LDS); P51RR000166-51 (AB).
• Keywords: Animals; Animals, Zoo; Female; Models, Animal; Macaca mulatta; Macaca fascicularis; Drug Evaluation, Preclinical; Primates; Animal Experimentation; Primate Diseases; Male; Biomedical Research; Animals, Wild
• Research Categories: Health Sciences, Epidemiology; Agriculture, Animal Pathology; Health Sciences, Pharmacy

Abstract

The combination of loss of habitat, human population encroachment, and increased demand of select nonhuman primates for biomedical research has significantly affected populations. There remains a need for knowledge and expertise in understanding background findings as related to the age, source, strain, and disease status of nonhuman primates. In particular, for safety/biomedical studies, a broader understanding and documentation of lesions would help clarify background from drug-related findings. A workshop and a minisymposium on spontaneous lesions and diseases in nonhuman primates were sponsored by the concurrent Annual Meetings of the American College of Veterinary Pathologists and the American Society for Veterinary Clinical Pathology held December 3-4, 2011, in Nashville, Tennessee. The first session had presentations from Drs Lowenstine and Montali, pathologists with extensive experience in wild and zoo populations of nonhuman primates, which was followed by presentations of 20 unique case reports of rare or newly observed spontaneous lesions in nonhuman primates (see online files for access to digital whole-slide images corresponding to each case report at http://www.scanscope.com/ACVP%20Slide%20Seminars/2011/Primate%20Pathology/view.apml). The minisymposium was composed of 5 nonhuman-primate researchers (Drs Bradley, Cline, Sasseville, Miller, Hutto) who concentrated on background and spontaneous lesions in nonhuman primates used in drug safety studies. Cynomolgus and rhesus macaques were emphasized, with some material presented on common marmosets. Congenital, acquired, inflammatory, and neoplastic changes were highlighed with a focus on clinical, macroscopic, and histopathologic findings that could confound the interpretation of drug safety studies.