Advancing Research on the Complex Interrelations Between Atrial Fibrillation and Heart Failure A Report From a US National Heart, Lung, and Blood Institute Virtual Workshop

• Type of Material: Article
• Authors: Sana M Al-Khatib, Duke University; Emelia J Benjamin, Boston University; Christine M Albert, Cedars Sinai Medical Center; Alvaro Alonso, Emory University; Cynthia Chauhan, Patient Representat; Peng-Sheng Chen, Indiana University School of Medicine; Anne B Curtis, University at Buffalo; Patrice Desvigne-Nickens, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda; Jennifer E Ho, Harvard Medical School; Carolyn SP Lam, National Heart Centre Singapore and Duke-National University of Singapore; Mark S Link, UT Southwestern Medical Center, Dallas; Kristen K Patton, University of Washington; Margaret M Redfield, Mayo Clinic in Rochester; Michiel Rienstra, University of Groningen; Yves Rosenberg, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda; Renate Schnabel, University Heart Center Hamburg; John A Spertus, Saint Luke’s Mid America Heart Institute/UMKC, Kansas City; Lynne Warner Stevenson, Vanderbilt University; Mellanie True Hills, American Foundation for Women’s Health; Adriaan A Voors, University of Groningen; Lawton S Cooper, Vanderbilt University; Alan S Go, Kaiser Permanente Northern Calif
• Language: English
• Date: 2020-06-09
• Publisher: LIPPINCOTT WILLIAMS & WILKINS
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2020, Wolters Kluwer Health
• Final Published Version (URL): http://dx.doi.org/10.1161/CIRCULATIONAHA.119.045204
• Title of Journal or Parent Work: CIRCULATION
• Volume: 141
• Issue: 23
• Start Page: 1915
• End Page: 1926
• Grant/Funding Information: None
• Keywords: QUALITY-OF-LIFE; Science & Technology; PREVENTION; heart failure; atrial fibrillation; Cardiac & Cardiovascular Systems; Peripheral Vascular Disease; Cardiovascular System & Cardiology; DYSFUNCTION; VAGUS NERVE-STIMULATION; NATRIURETIC PEPTIDE; CATHETER ABLATION; Life Sciences & Biomedicine; PRESERVED EJECTION FRACTION; MECHANISMS; research; RISK; OUTCOMES

Abstract

The interrelationships between atrial fibrillation (AF) and heart failure (HF) are complex and poorly understood, yet the number of patients with AF and HF continues to increase worldwide. Thus, there is a need for initiatives that prioritize research on the intersection between AF and HF. This article summarizes the proceedings of a virtual workshop convened by the US National Heart, Lung, and Blood Institute to identify important research opportunities in AF and HF. Key knowledge gaps were reviewed and research priorities were proposed for characterizing the pathophysiological overlap and deleterious interactions between AF and HF; preventing HF in people with AF; preventing AF in individuals with HF; and addressing symptom burden and health status outcomes in AF and HF. These research priorities will hopefully help inform, encourage, and stimulate innovative, cost-efficient, and transformative studies to enhance the outcomes of patients with AF and HF.