Evaluation of viral co-infections among patients with community-associatedClostridioides difficileinfection

• Type of Material: Article
• Authors: Lauren Korhonen, Centers for Disease Control and Prevention; Jessica Cohen, Centers for Disease Control and Prevention; Nicole Gregoricus, Centers for Disease Control and Prevention; Monica Farley, Emory University; Rebecca Perlmutter, Maryland Department of Health; Stacy M. Holzbauer, Minnesota Department of Health; Ghinwa Dumyati, University of Rochester; Zintars Beldavs, Oregon Health Authority; Ashley Paulick, Centers for Disease Control and Prevention; Jan Vinje, Centers for Disease Control and Prevention; Brandi M. Limbago, Centers for Disease Control and Prevention; Fernanda C. Lessa, Centers for Disease Control and Prevention; Alice Y. Guh, Centers for Disease Control and Prevention
• Language: English
• Date: 2020-10-19
• Publisher: PUBLIC LIBRARY SCIENCE
• Publication Version: Final Published Version
• Copyright Statement: This is an open access article, free of all copyright
• License: Creative Commons Universal : Public Domain Dedication
• Final Published Version (URL): http://dx.doi.org/10.1371/journal.pone.0240549
• Title of Journal or Parent Work: PLOS ONE
• Volume: 15
• Issue: 10
• Start Page: e0240549
• End Page: e0240549
• Grant/Funding Information: This work was funded by the Centers for Disease Control and Prevention, which had a role in study design, date collection and analysis, decision to publish, and preparation of the manuscript.
• Keywords: ACUTE GASTROENTERITIS; NOROVIRUS; ETIOLOGY; CLOSTRIDIUM-DIFFICILE; Science & Technology; Multidisciplinary Sciences; PANEL; Science & Technology - Other Topics; MULTICENTER
• Research Categories: Biology, Virology

Abstract

We assessed viral co-infections in 155 patients with community-associated Clostridioides difficile infection in five U.S. sites during December 2012–February 2013. Eighteen patients (12%) tested positive for norovirus (n = 10), adenovirus (n = 4), rotavirus (n = 3), or sapovirus (n = 1). Co-infected patients were more likely than non-co-infected patients to have nausea or vomiting (56% vs 31%; p = 0.04), suggesting that viral co-pathogens contributed to symptoms in some patients. There were no significant differences in prior healthcare or medication exposures or in CDI complications.