Big bottlenecks in cardiovascular tissue engineering.

• Type of Material: Article
• Authors: Ngan F. Huang, Stanford University; Vahid Serpooshan, Emory University; Viola B. Morris, Georgia Institute of Technology; Nazish Sayed, Stanford University; Gaspard Pardon, Stanford University; Oscar J. Abilez, Stanford University; Karina H. Nakayama, Stanford University; Beth L. Pruitt, Stanford University; Sean M. Wu, Stanford University; Young-sup Yoon, Emory University; Jianyi Zhang, University of Alabama at Birmingham; Joseph C. Wu, Stanford University
• Language: English
• Date: 2018
• Publisher: Nature Research (part of Springer Nature): Fully open access journals
• Publication Version: Final Published Version
• Copyright Statement: © This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply 2018
• License: Creative Commons Attribution 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1038/s42003-018-0202-8
• Title of Journal or Parent Work: Communications Biology
• ISSN: 2399-3642
• Volume: 1
• Start Page: 199
• End Page: 199
• Grant/Funding Information: We also gratefully acknowledge support of the symposium by the National Institutes of Health Progenitor Cell Biology Consortium (HL099997).
• Keywords: roadblocks; Pluripotent stem cells; Cardiology; Tissue Engineering; Cardiovascular Tissue
• Research Categories: Health Sciences, General; Biology, Cell

Abstract

Although tissue engineering using human-induced pluripotent stem cells is a promising approach for treatment of cardiovascular diseases, some limiting factors include the survival, electrical integration, maturity, scalability, and immune response of three-dimensional (3D) engineered tissues. Here we discuss these important roadblocks facing the tissue engineering field and suggest potential approaches to overcome these challenges.