United States Influenza 2022–2023 Season Characteristics as Inferred from Wastewater Solids, Influenza Hospitalization, and Syndromic Data

• Type of Material: Article
• Authors: Mary E. Schoen, Soller Environmental; Amanda L. Bidwell, Stanford University; Marlene Wolfe, Emory University; Alexandria B. Boehm, Stanford University
• Language: English
• Date: 2023-11-28
• Publisher: American Chemical Society
• Publication Version: Final Published Version
• Copyright Statement: © 2023 The Authors. Published by American Chemical Society
• License: Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International
• Final Published Version (URL): https://doi.org/10.1021/acs.est.3c07526
• Title of Journal or Parent Work: Environmental Science and Technology
• Volume: 57
• Issue: 49
• Start Page: 20542
• End Page: 20550
• Grant/Funding Information: This work was supported by gifts from the CDC Foundation and the Sergey Brin Family Foundation to A.B.B.
• Keywords: onset; epidemic pattern; baseline; influenza A; wastewater-based epidemiology
• Research Categories: Health Sciences, Epidemiology; Health Sciences, Public Health; Environmental Sciences

Abstract

Influenza A virus (IAV) causes significant morbidity and mortality in the United States and has pandemic potential. Identifying IAV epidemic patterns is essential to inform the timing of vaccinations and nonpharmaceutical interventions. In a prospective, longitudinal study design, we measured IAV RNA in wastewater settled solids at 163 wastewater treatment plants across 33 states to characterize the 2022–2023 influenza season at the state, health and human services (HHS) regional, and national scales. Influenza season onset, offset, duration, peak, and intensity using IAV RNA in wastewater were compared with those determined using laboratory-confirmed influenza hospitalization rates and outpatient visits for influenza-like illness (ILI). The onset for HHS regions as determined by IAV RNA in wastewater roughly corresponded with those determined using ILI when the annual geometric mean of IAV RNA concentration was used as a baseline (i.e., the threshold that triggers onset), although offsets between the two differed. IAV RNA in wastewater provided early warning of onset, compared to the ILI estimate, when the baseline was set at twice the limit of IAV RNA detection in wastewater. Peak when determined by IAV RNA in wastewater generally preceded peak determined by IAV hospitalization rate by 2 weeks or less. IAV RNA in wastewater settled solids is an IAV-specific indicator that can be used to augment clinical surveillance for seasonal influenza epidemic timing and intensity.