Publication

Prism adaptation and spatial neglect: the need for dose-finding studies

Downloadable Content

Persistent URL
Last modified
  • 05/15/2025
Type of Material
Authors
    Kelly M. Goedert, Seton Hall UniversityJeffrey Y. Zhang, Princeton PharmatechAnna Barrett, Emory University
Language
  • English
Date
  • 2015-04-30
Publisher
  • Frontiers Media
Publication Version
Copyright Statement
  • © 2015 Goedert, Zhang and Barrett.
License
Final Published Version (URL)
Title of Journal or Parent Work
ISSN
  • 1662-5161
Volume
  • 9
Issue
  • APR
Start Page
  • 243
End Page
  • 243
Grant/Funding Information
  • This work was supported by funding from the Kessler Foundation; the National Institutes of Health; and the National Institute of Disability and Rehabilitation Research (Grant Numbers R01 NS 055808;, K24 HD062647;, H133 G120203 PI: Barrett).
Abstract
  • Spatial neglect is a devastating disorder in 50–70% of right-brain stroke survivors, who have problems attending to, or making movements towards, left-sided stimuli, and experience a high risk of chronic dependence. Prism adaptation is a promising treatment for neglect that involves brief, daily visuo-motor training sessions while wearing optical prisms. Its benefits extend to functional behaviors such as dressing, with effects lasting 6 months or longer. Because one to two sessions of prism adaptation induce adaptive changes in both spatial-motor behavior (Fortis et al., 2011) and brain function (Saj et al., 2013), it is possible stroke patients may benefit from treatment periods shorter than the standard, intensive protocol of ten sessions over two weeks—a protocol that is impractical for either US inpatient or outpatient rehabilitation. Demonstrating the effectiveness of a lower dose will maximize the availability of neglect treatment. We present preliminary data suggesting that four to six sessions of prism treatment may induce a large treatment effect, maintained three to four weeks post-treatment. We call for a systematic, randomized clinical trial to establish the minimal effective dose suitable for stroke intervention.
Author Notes
  • Correspondence: Kelly M. Goedert, Department of Psychology, Seton Hall University, 400 South Orange Ave. South Orange, NJ 07079, USA kelly.goedert@shu.edu
Keywords
Research Categories
  • Psychology, General
  • Biology, Neuroscience

Tools

Relations

In Collection:

Items

Thumbnail Title File Description Date Uploaded Visibility Actions
file details Publication File - vds02.pdf Primary Content 2025-04-08 Public Download