Publication

Impaired Cognitive Flexibility After Neonatal Perirhinal Lesions in Rhesus Macaques

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Last modified
  • 05/21/2025
Type of Material
Authors
    Alison R. Weiss, Emory UniversityJessica White, Emory UniversityRebecca Richardson, Emory UniversityJocelyne Bachevalier, Emory University
Language
  • English
Date
  • 2019-01-30
Publisher
  • Frontiers Media
Publication Version
Copyright Statement
  • © 2019 Weiss, White, Richardson and Bachevalier.
License
Final Published Version (URL)
Title of Journal or Parent Work
ISSN
  • 1662-5137
Volume
  • 13
Start Page
  • 6
End Page
  • 6
Grant/Funding Information
  • This work was supported by the National Institute of Mental Health (MH-58846 to JB and T32-HD071845 to AW), the National Science Foundation (NSF-GRFP DGE-1444932 to AW), and the National Center for Research Resources P51RR165, currently supported by the Office of Research Infrastructure Programs/OD P51OD11132.
Abstract
  • Previous research indicated that monkeys with neonatal perirhinal lesions (Neo-PRh) were impaired on working memory (WM) tasks that generated proactive interference, but performed normally on WM tasks devoid of interference (Weiss et al., 2016). This finding suggested that the early lesions disrupted cognitive processes important for resolving proactive interference, such as behavioral inhibition and cognitive flexibility. To distinguish between these possibilities, the same Neo-PRh monkeys and their controls were tested using the Intradimensional/Extradimensional attentional set-shifting task (Roberts et al., 1988; Dias et al., 1997). Neo-PRh monkeys completed the Simple and Compound Discrimination stages, the Intradimensional Shift stage, and all Reversal stages comparably to controls, but made significantly more errors on the Extradimensional Shift stage of the task. These data indicate that impaired cognitive flexibility was the likely source of increased perseverative errors made by Neo-PRh monkeys when performing WM tasks, rather than impaired behavioral inhibition, and imply that the perirhinal cortex and its interactions with the PFC may play a unique and critical role in the development of attentional set shifting abilities.
Author Notes
Keywords
Research Categories
  • Psychology, Cognitive
  • Biology, Neuroscience

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