Internal consistency and item-total correlation of patient-reported outcome instruments and hemophilia joint health score v2.1 in US adult people with hemophilia: results from the Pain, Functional Impairment, and Quality of life (P-FiQ) study

• Type of Material: Article
• Authors: Michael Wang, University of Colorado; Katharine Batt, Wake Forest School of Medicine; Craig Kessler, Georgetown University Hospital; Anne Neff, Cleveland Clinic; Neeraj N. Iyer, Novo Nordisk Inc.; David L. Cooper, Novo Nordisk Inc.; Christine Kempton, Emory University
• Language: English
• Date: 2017-01-01
• Publisher: Dove Medical Press
• Publication Version: Final Published Version
• Copyright Statement: © 2017 Wang et al.
• License: Creative Commons Attribution-Noncommercial 3.0 Unported
• Final Published Version (URL): http://dx.doi.org/10.2147/PPA.S141391
• Title of Journal or Parent Work: Patient Preference and Adherence
• ISSN: 1177-889X
• Volume: 11
• Start Page: 1831
• End Page: 1839
• Grant/Funding Information: Writing assistance was provided by Anna Abt, PhD, of ETHOS Health Communications, Yardley, Pennsylvania, and was supported financially by Novo Nordisk Inc., Plainsboro, New Jersey, in compliance with international Good Publication Practice guidelines.; The P-FiQ study was managed by Quintiles Real World and Late Phase, Boston, Massachusetts, and Rockville, Maryland, with statistical analyses provided by Jennifer James, Senior Biostatistician, and was supported financially by Novo Nordisk Inc.
• Keywords: quality of life; hemophilia; VALIDITY; PHYSICAL-ACTIVITY; ASSESSMENTS; VALIDATION; pain; ACTIVITIES LIST; Science & Technology; Life Sciences & Biomedicine; Medicine, General & Internal; MANAGEMENT; ABILITIES; CONGENITAL HEMOPHILIA; INHIBITORS; RELIABILITY; patient-reported outcome; joint health; General & Internal Medicine; functional impairment
• Research Categories: Health Sciences, Oncology; Health Sciences, General; Health Sciences, Pathology

Abstract

Background: The Pain, Functional Impairment, and Quality of Life study was an observational, cross-sectional assessment of the impact of pain on functional impairment and quality of life in adult people with hemophilia (PWH) of any severity in the USA who experience joint pain and/or bleeding. Objective: To assess internal consistency (IC) and item-total correlation (ITC) of assessment tools used in the Pain, Functional Impairment, and Quality of Life study. Methods: Participants completed 5 patient-reported outcome instruments (EQ-5D-5L with visual analog scale, Brief Pain Inventory v2 Short Form [BPI], International Physical Activity Questionnaire [IPAQ] , Short Form 36 Health Survey v2 [SF-36v2], and Hemophilia Activities List [HAL] ) and underwent an optional physiotherapist-administered musculoskeletal exam (Hemophilia Joint Health Score v2.1) during routine visits. Reliability assessment included IC and ITC of each instrument. Results: A total of 381 adult PWH (median age, 34 years) were enrolled. Participants were predominantly white/non-Hispanic (69.2%); 75% had congenital hemophilia A, and 70.5% had severe hemophilia. A total of 310 subjects reported bleeding within the past 6 months (mean [SD] number of bleeds, 7.1 [13.00] ). IC was generally high across the instruments employed (Cronbach’s alpha 0.79-0.98) with the exception of HAL use of transportation (0.58) and IPAQ total physical activity (0.51). ITC was high (Pearson’s product-moment correlation coefficient.0.20) for all items except the “vigorous intensity activities” item of IPAQ, which was applicable to less than one-third of participants. The ITCs were generally highest in domains/scores that measured the functional consequences of hemophilic arthropathy on mobility and pain. Conclusion: The demonstrated reliability (IC/ITC) of the patient-reported outcome instruments and Hemophilia Joint Health Score v2.1 support a role for these instruments in evaluating adult PWH in US clinical and research settings.