Deep Brain Stimulation Initiative: Toward Innovative Technology, New Disease Indications, and Approaches to Current and Future Clinical Challenges in Neuromodulation Therapy

• Type of Material: Article
• Authors: Yanan Sui, Tsinghua University; Ye Tian, Tsinghua University; Wai Kin Daniel Ko, Tsinghua University; Zhiyan Wang, Tsinghua University; Fumin Jia, Tsinghua University; Andreas Horn, University Medicine Berlin; Dirk De Ridder, University of Otago; Ki Choi, Emory University; Ausaf A. Bari, University of California, Los Angeles; Shouyan Wang, Fudan University; Clement Hamani, Sunnybrook Research Institute; Kenneth B. Baker, Cleveland Clinic; Andre G. Machado, Cleveland Clinic; Tipu Z. Aziz, University of Oxford; Erich Talamoni Fonoff, University of São Paulo Medical School; Andrea A. Kuhn, University Medicine Berlin; Hagai Bergman, Institute of Medical Research–Israel-Canada; Terence Sanger, University of Southern California; Hesheng Liu, Medical University of South Carolina; Suzanne N. Haber, University of Rochester; Luming Li, Tsinghua University
• Language: English
• Date: 2021-01-28
• Publisher: FRONTIERS MEDIA SA
• Publication Version: Final Published Version
• Copyright Statement: © 2021 Sui, Tian, Ko, Wang, Jia, Horn, De Ridder, Choi, Bari, Wang, Hamani, Baker, Machado, Aziz, Fonoff, Kühn, Bergman, Sanger, Liu, Haber and Li.
• License: Creative Commons Attribution 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.3389/fneur.2020.597451
• Title of Journal or Parent Work: FRONTIERS IN NEUROLOGY
• Volume: 11
• Start Page: 597451
• End Page: 597451
• Keywords: depression; gait disability; Science & Technology; Neurosciences; Clinical Neurology; neuromoxdulation; Life Sciences & Biomedicine; Neurosciences & Neurology; deep brain stimulation; MRI compatibility
• Research Categories: Biology, Physiology; Biology, Neuroscience

Abstract

Deep brain stimulation (DBS) is one of the most important clinical therapies for neurological disorders. DBS also has great potential to become a great tool for clinical neuroscience research. Recently, the National Engineering Laboratory for Neuromodulation at Tsinghua University held an international Deep Brain Stimulation Initiative workshop to discuss the cutting-edge technological achievements and clinical applications of DBS. We specifically addressed new clinical approaches and challenges in DBS for movement disorders (Parkinson's disease and dystonia), clinical application toward neurorehabilitation for stroke, and the progress and challenges toward DBS for neuropsychiatric disorders. This review highlighted key developments in (1) neuroimaging, with advancements in 3-Tesla magnetic resonance imaging DBS compatibility for exploration of brain network mechanisms; (2) novel DBS recording capabilities for uncovering disease pathophysiology; and (3) overcoming global healthcare burdens with online-based DBS programming technology for connecting patient communities. The successful event marks a milestone for global collaborative opportunities in clinical development of neuromodulation to treat major neurological disorders.