Vascular Disease and Thrombosis in SARS-CoV-2-Infected Rhesus Macaques

• Type of Material: Article
• Authors: Malika Aid, Beth Israel Deaconess Medical Center; Kathleen Busman-Sahay, Oregon Health & Science University; Samuel J. Vidal, Beth Israel Deaconess Medical Center; Zoltan Maliga, Harvard Medical School; Stephen Bondoc, Oregon Health & Science University; Carly Starke, Oregon Health & Science University; Margaret Terry, Oregon Health & Science University; Connor A. Jacobson, Harvard Medical School; Linda Wrijil, Tufts University; Sarah Ducat, Tufts University; Olga R. Brook, Harvard Medical School; Andrew D. Miller, Cornell University; Maciel Porto, Bioqual; Kathryn L. Pellegrini, Emory University; Maria Pino, Emory University; Timothy N. Hoang, Emory University; Abishek Chandrashekar, Beth Israel Deaconess Medical Center; Shivani Patel, Beth Israel Deaconess Medical Center; Kathryn Stephenson, Beth Israel Deaconess Medical Center; Steven Bosinger, Emory University; Hanne Andersen, Bioqual; Mark G. Lewis, Bioqual; Jonathan L. Hecht, Beth Israel Deaconess Medical Center; Peter K. Sorger, Harvard Medical School; Amanda J. Martinot, Beth Israel Deaconess Medical Center; Jacob D. Estes, Oregon Health & Science University; Dan H. Barouch, Beth Israel Deaconess Medical Center
• Language: English
• Date: 2020-11-25
• Publisher: CELL PRESS
• Publication Version: Final Published Version
• Copyright Statement: © 2020 Elsevier Inc.
• Final Published Version (URL): http://dx.doi.org/10.1016/j.cell.2020.10.005
• Title of Journal or Parent Work: CELL
• Volume: 183
• Issue: 5
• Start Page: 1354
• End Page: +
• Grant/Funding Information: We acknowledge support from the Ragon Institute of MGH, MIT and Harvard; Mark and Lisa Schwartz Foundation; Beth Israel Deaconess Medical Center; Massachusetts Consortium on Pathogen Readiness (MassCPR); Bill & Melinda Gates Foundation (INV-006131); and the National Institutes of Health (OD024917, CA260476, AI124377, AI126603, AI128751, AI129797, and AI149670). The Yerkes Genomics Core is supported in part by NIH P51 OD011132, and sequencing data were acquired on an Illumina NovaSeq6000 funded by NIH S10 OD026799.
• Keywords: INTERFERON; Science & Technology; Biochemistry & Molecular Biology; COMPLEMENT; ACTIVATION; Cell Biology; ENRICHMENT ANALYSIS; INFECTION; CELLS; Life Sciences & Biomedicine
• Research Categories: Biology, Cell; Biology, Molecular; Chemistry, Biochemistry

Abstract

Aid et al. show that SARS-CoV-2 causes endothelial disruption and vascular thrombosis in both human and rhesus macaques lungs by inducing an upregulation of proinflammatory cytokines. Using an approach that combines histopathology and multiomics in macaques, they show the progression to vascular disease over time, which involves complement, macrophage, cytokine, and thrombosis cascades.