Association of Secretor Status and Recent Norovirus Infection With Gut Microbiome Diversity Metrics in a Veterans Affairs Population

• Type of Material: Article
• Authors: Jordan A Johnson, Emory University; Timothy Read, Emory University; Robert A III, Petit, Emory University; Vincent Marconi, Emory University; Kathryn L Meagley, Emory University; Maria C Rodriguez-Barradas, Michael E DeBakey VA Med Ctr; David O Beenhouwer, Veterans Affairs Greater Los Angeles Health System; Sheldon T Brown, James J. Peters Veterans Affairs Medical Center; Mark Holodniy, Veterans Affairs Palo Alto Health Care System; Cynthia A Lucero-Obusan, Veterans Affairs Palo Alto Health Care System; Patricia Schirmer, Veterans Affairs Palo Alto Health Care System; Jessica Ingersoll, Emory University; Colleen Kraft, Emory University; Frederick H Neill, Baylor College of Medicine; Robert L Atmar, Veterans Health Administration; Anita K Kambhampati, Centers for Disease Control and Prevention; Jordan E Cates, Centers for Disease Control and Prevention; Sara A Mirza, Centers for Disease Control and Prevention; Aron J Hall, Centers for Disease Control and Prevention; Cristina Cardemil, Emory University; Benjamin Lopman, Emory University
• Language: English
• Date: 2022-05-01
• Publisher: OXFORD UNIV PRESS INC
• Publication Version: Final Published Version
• Copyright Statement: © The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America.
• License: Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1093/ofid/ofac125
• Title of Journal or Parent Work: OPEN FORUM INFECTIOUS DISEASES
• Volume: 9
• Issue: 5
• Start Page: ofac125
• End Page: ofac125
• Grant/Funding Information: This work was supported by the Foundation for Atlanta Veterans Education and Outreach (FAVER; formerly the Atlanta Research and Education Foundation or AREF) and the Centers for Disease Control and Prevention, Atlanta, Georgia.
• Keywords: DISEASE; secretor status; HUMAN HEALTH; Infectious Diseases; Life Sciences & Biomedicine; Science & Technology; Microbiology; norovirus; acute gastroenteritis; microbiome; Immunology
• Research Categories: Health Sciences, Epidemiology; Health Sciences, Pathology

Abstract

Norovirus infection causing acute gastroenteritis could lead to adverse effects on the gut microbiome. We assessed the association of microbiome diversity with norovirus infection and secretor status in patients from Veterans Affairs medical centers. Alpha diversity metrics were lower among patients with acute gastroenteritis but were similar for other comparisons.