Diabetes Mellitus and Cause-Specific Mortality: A Population-Based Study

• Type of Material: Article
• Authors: Sen Li, Beijing University of Chinese Medicine; Jiaxin Wang, Beijing University of Chinese Medicine; Biao Zhang, Chinese Academy of Medical Sciences; Xinyi Li, Beijing University of Chinese Medicine; Yuan Liu, Emory University
• Language: English
• Date: 2019-06-01
• Publisher: Korean Diabetes Association
• Publication Version: Final Published Version
• Copyright Statement: © 2019 Korean Diabetes Association
• License: Creative Commons Attribution-NonCommercial 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.4093/dmj.2018.0060
• Title of Journal or Parent Work: Diabetes and Metabolism Journal
• ISSN: 2233-6079
• Volume: 43
• Issue: 3
• Start Page: 319
• End Page: 341
• Grant/Funding Information: This study is supported by the National Natural Science Foundation of China (Grant No. 81703942), Science Fund for Distinguished Young Scholars in BUCM (Grant No. BUCM-2019-JCRC004) and BUCM research program (to Sen Li).
• Keywords: WORKING-AGE ADULTS; ALL-CAUSE MORTALITY; ASSOCIATION; CANCER; CEREBROVASCULAR-DISEASE; Life Sciences & Biomedicine; Mortality; Science & Technology; Endocrinology & Metabolism; RISK; Diabetes mellitus; ACCIDENTS; Diabetes complications; IMPACT; CARDIOVASCULAR-DISEASE; SUSCEPTIBILITY
• Research Categories: Biology, Biostatistics; Health Sciences, Epidemiology; Biology, Physiology

Abstract

Background: To investigate whether diabetes contributes to mortality for major types of diseases. Methods: Six National Health and Nutrition Examination Survey data cycles (1999 to 2000, 2001 to 2002, 2003 to 2004, 2005 to 2006, 2007 to 2008, and 2009 to 2010) and their linked mortality files were used. A population of 15,513 participants was included according to the availability of diabetes and mortality status. Results: Participants with diabetes tended to have higher all-cause mortality and mortality due to cardiovascular disease, cancer, chronic lower respiratory diseases, cerebrovascular disease, influenza and pneumonia, and kidney disease. Confounder-adjusted Cox proportional hazard models showed that both diagnosed diabetes category (yes or no) and diabetes status (diabetes, prediabetes, or no diabetes) were associated with all-cause mortality and with mortality due to cardiovascular disease, chronic lower respiratory diseases, influenza and pneumonia, and kidney disease. No associations were found for cancer-, accidents-, or Alzheimer's disease-related mortality. Conclusion: The current study's findings provide epidemiological evidence that diagnosed diabetes at the baseline is associated with increased mortality risk due to cardiovascular disease, chronic lower respiratory diseases, influenza and pneumonia, and kidney disease, but not with cancer or Alzheimer's disease.