Author Correction: YB1 modulates the DNA damage response in medulloblastoma

• Type of Material: Article
• Authors: Leon McSwain, Emory University; Claire Pillsbury, Emory University; Ramonasadat Haji Seyed Javadi, Emory University; Sandip Kumar Rath, Emory University; Victor Chen, Emory University; Tiffany Huang, Emory University; Shubin Shahab, Emory University; Haritha Kunhiraman, Emory University; James Ross, Emory University; Gabrielle A. Price, Icahn School of Medicine at Mount Sinai; Abhinav Dey, Emory University; Dolares Hambardzumyan, Emory University; Tobey MacDonald, Emory University; David Yu, Emory University; Christopher Porter, Emory University; Anna M. Kenney, Emory University
• Language: English
• Date: 2023-06-15
• Publisher: Nature
• Publication Version: Final Published Version
• Copyright Statement: © The Author(s) 2023
• License: Creative Commons Attribution 4.0 International
• Final Published Version (URL): https://doi.org/10.1038%2Fs41598-023-36594-3
• Title of Journal or Parent Work: Scientific Reports
• Volume: 13
• Start Page: 9717
• Keywords: Paediatric cancer; Oncology; Cell biology; Cancer
• Research Categories: Health Sciences, Oncology; Biology, Cell

Abstract

The original version of this Article contained errors in the legends of Figures 1, 2, 3, 4, 5, 6 and 7. In Figure legend 1, “YB1 is expressed across all MB subgroups and overexpression is associated with shortened survival in an SHH primary mouse model.” now reads: “YB1 is expressed across all MB subgroups and overexpression is associated with shortened survival in an SHH primary mouse model (A) Immunoblotting cell lysate from SHH cells [MBC (primary NestinD2-SmoA1), Pzp53Med (Ptch-LacZ-p53null), Daoy, UW228, and ONS-76], and group 3/4 cells (D341, D556, BT52, D283, and CHLA01) with GAPDH as control. (B) Immunohistochemistry of SHH subgroup samples from both TP53 wild type and mutated patients showing positive staining of both Nestin (Stem marker) and YB1 (Left scale bar = 100 μm, quantification Supp Fig. 1a and b). (C) Survival analysis of BL6 mice orthotopically implanted with NestinD2-SmoA1 primary cells following adenoviral overexpression of YB1 (GFP median survival 26.5 days YB1 median survival 60.5 days p < 0.0001). (D) UMAP of previously published single cell sequencing analysis of SHH-Math-Cre-SmoM2 showing enrichment of YB1 in numerous cell populations collected from UCSC Cell Browser: active cell cycling (MS-A1 and MS-A2) and progenitor (MS-B1). Expression profile is subdivided into 10 expression ranges apart from no expression and percent of all cells within each range listed on right.”