The bidirectional relationship between CFTR and lipids

• Type of Material: Article
• Authors: Kirsten A. Cottrill, Emory University; Carlos M. Farinha, University of Lisbon; Nael McCarty, Emory University
• Language: English
• Date: 2020-04-20
• Publisher: NATURE PUBLISHING GROUP
• Publication Version: Final Published Version
• Copyright Statement: © 2020, The Author(s).
• License: Creative Commons Attribution 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1038/s42003-020-0909-1
• Title of Journal or Parent Work: COMMUNICATIONS BIOLOGY
• Volume: 3
• Issue: 1
• Start Page: 179
• End Page: 179
• Grant/Funding Information: This work is supported by grants MCCART17G0 and MCCART18G0 to N.A.M. from the CF Foundation. K.A.C. is supported by NIH 1 F31 HL143863-01.
• Keywords: ABC TRANSPORTERS; Science & Technology; Life Sciences & Biomedicine - Other Topics; CONFORMATIONAL-CHANGES; PLASMA-MEMBRANE; Life Sciences & Biomedicine; PSEUDOMONAS-AERUGINOSA; Multidisciplinary Sciences; LONG-CHAIN CERAMIDES; Science & Technology - Other Topics; APICAL MEMBRANE; TEZACAFTOR-IVACAFTOR; CYSTIC-FIBROSIS-PATIENTS; TRANSMEMBRANE CONDUCTANCE REGULATOR; ATPASE ACTIVITY; Biology
• Research Categories: Biology, General; Health Sciences, Pharmacology

Abstract

Cystic Fibrosis (CF) is the most common life-shortening genetic disease among Caucasians, resulting from mutations in the gene encoding the Cystic Fibrosis Transmembrane conductance Regulator (CFTR). While work to understand this protein has resulted in new treatment strategies, it is important to emphasize that CFTR exists within a complex lipid bilayer — a concept largely overlooked when performing structural and functional studies. In this review we discuss cellular lipid imbalances in CF, mechanisms by which lipids affect membrane protein activity, and the specific impact of detergents and lipids on CFTR function.