Higher soluble CD163 in blood is associated with significant depression symptoms in men with HIV

• Type of Material: Article
• Authors: Albert Anderson, Emory University; Fiona Bhondoekhan, Johns Hopkins University; Dusica Curanovic, Labcorp; Margery A. Connelly, Labcorp; James D. Otvos, Labcorp; Wendy S. Post, Johns Hopkins University; Erin D. Michos, Johns Hopkins University; Valentina Stosor, Northwestern University; Andrew Levine, University of California, Los Angeles; Eric Seaberg, Johns Hopkins University; Andrea M. Weinstein, University of Pittsburgh; James T. Becker, University of Pittsburgh
• Language: English
• Date: 2022-11-01
• Publisher: Wolters Kluwer Health, Inc.
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2022 Wolters Kluwer Health, Inc. All rights reserved.
• Final Published Version (URL): https://doi.org/10.1097/QAI.0000000000003063
• Title of Journal or Parent Work: JAIDS: Journal of Acquired Immune Deficiency Syndrome
• Volume: 91
• Issue: 3
• Start Page: 325
• End Page: 333
• Grant/Funding Information: MWCCS (Principal Investigators): Atlanta CRS (Ighovwerha Ofotokun, Anandi Sheth, and Gina Wingood), U01-HL146241; Baltimore CRS (Todd Brown and Joseph Margolick), U01-HL146201; Bronx CRS (Kathryn Anastos and Anjali Sharma), U01-HL146204; Brooklyn CRS (Deborah Gustafson and Tracey Wilson), U01-HL146202; Data Analysis and Coordination Center (Gypsyamber D’Souza, Stephen Gange and Elizabeth Golub), U01-HL146193; Chicago-Cook County CRS (Mardge Cohen and Audrey French), U01-HL146245; Chicago-Northwestern CRS (Steven Wolinsky), U01-HL146240; Northern California CRS (Bradley Aouizerat, Jennifer Price, and Phyllis Tien), U01-HL146242; Los Angeles CRS (Roger Detels and Matthew Mimiaga), U01-HL146333; Metropolitan Washington CRS (Seble Kassaye and Daniel Merenstein), U01-HL146205; Miami CRS (Maria Alcaide, Margaret Fischl, and Deborah Jones), U01-HL146203; Pittsburgh CRS (Jeremy Martinson and Charles Rinaldo), U01-HL146208; UAB-MS CRS (Mirjam-Colette Kempf, Jodie Dionne-Odom, and Deborah Konkle-Parker), U01-HL146192; UNC CRS (Adaora Adimora), U01-HL146194. The MWCCS is funded primarily by the National Heart, Lung, and Blood Institute (NHLBI), with additional co-funding from the Eunice Kennedy Shriver National Institute Of Child Health & Human Development (NICHD), National Institute On Aging (NIA), National Institute Of Dental & Craniofacial Research (NIDCR), National Institute Of Allergy And Infectious Diseases (NIAID), National Institute Of Neurological Disorders And Stroke (NINDS), National Institute Of Mental Health (NIMH), National Institute On Drug Abuse (NIDA), National Institute Of Nursing Research (NINR), National Cancer Institute (NCI), National Institute on Alcohol Abuse and Alcoholism (NIAAA), National Institute on Deafness and Other Communication Disorders (NIDCD), National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institute on Minority Health and Health Disparities (NIMHD), and in coordination and alignment with the research priorities of the National Institutes of Health, Office of AIDS Research (OAR). MWCCS data collection is also supported by UL1-TR000004 (UCSF CTSA), UL1-TR003098 (JHU ICTR), UL1-TR001881 (UCLA CTSI), P30-AI-050409 (Atlanta CFAR), P30-AI-073961 (Miami CFAR), P30-AI-050410 (UNC CFAR), P30-AI-027767 (UAB CFAR), and P30-MH-116867 (Miami CHARM). The authors gratefully acknowledge funding from the following sources: K23 MH095679, R21 MH118092, R01 AG062387 (Principal Investigator: A. Anderson); RO1 HL095129 (Principal Investigator: W. Post), P30AI094189 (Johns Hopkins Center for AIDS Research) and P30AI050409 (Emory Center for AIDS Research).
• Keywords: Antiretroviral Therapy; Depression; HIV; sCD163
• Research Categories: Health Sciences, Mental Health; Health Sciences, Public Health

Abstract

Background People with HIV (PWH) are more likely to experience depression, a highly morbid disease. More evidence is needed to better understand mechanisms of depression in PWH. We evaluated a panel of blood biomarkers in relation to depression symptoms in the Multicenter AIDS Cohort Study (MACS). Setting Four sites in the United States Methods A cross-sectional analysis was performed within the MACS, a prospective study of cisgender men with and without HIV. Depression was assessed with the Center for Epidemiological Studies-Depression (CES-D) scale, and six blood biomarkers were measured: GlycA, high sensitivity C-reactive protein (CRP), interleukin-6 (IL-6), CCL2, soluble CD14 (sCD14), and soluble CD163 (sCD163). Using univariable and multivariable logistic regression, the biomarkers and other factors were evaluated in relation to significant depression symptoms (SDS) by CES-D score ≥16. Results 784 men were analyzed, the majority of whom (63%) were PWH. PWH were more likely to have SDS (32% versus 21%). In univariable analysis, higher GlycA, CRP, and sCD163 concentration were associated with SDS. In multivariable analysis, however, only higher sCD163 concentration was associated with SDS (OR=2.30, 95%CI=1.11, 4.76). This relationship was driven by the PWH group (OR=2.72, 95%CI=1.12, 6.58) and remained significant when controlling for antidepressant use. Lack of college education was also associated with SDS. Conclusions Higher sCD163, a marker of macrophage activation, was significantly associated with significant depression symptoms in the MACS. Further research on this biomarker and macrophage activation in general is warranted to better understand and treat depression in PWH.