Publication

Stereotactic Laser Ablation for Medically Intractable Epilepsy: The Next Generation of Minimally Invasive Epilepsy Surgery.

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Last modified
  • 02/20/2025
Type of Material
Authors
    Michael J. LaRiviere, University of PennsylvaniaRobert Gross, Emory University
Language
  • English
Date
  • 2016
Publisher
  • Frontiers Media
Publication Version
Copyright Statement
  • © 2016 LaRiviere and Gross.
License
Final Published Version (URL)
Title of Journal or Parent Work
ISSN
  • 2296-875X
Volume
  • 3
Start Page
  • 64
End Page
  • 64
Grant/Funding Information
  • This work was funded in part by a grant from Visualase, Inc.
Abstract
  • Epilepsy is a common, disabling illness that is refractory to medical treatment in approximately one-third of patients, particularly among those with mesial temporal lobe epilepsy. While standard open mesial temporal resection is effective, achieving seizure freedom in most patients, efforts to develop safer, minimally invasive techniques have been underway for over half a century. Stereotactic ablative techniques, in particular, radiofrequency (RF) ablation, were first developed in the 1960s, with refinements in the 1990s with the advent of modern computed tomography and magnetic resonance-based imaging. In the past 5 years, the most recent techniques have used MRI-guided laser interstitial thermotherapy (LITT), the development of which began in the 1980s, saw refinements in MRI thermal imaging through the 1990s, and was initially used primarily for the treatment of intracranial and extracranial tumors. The present review describes the original stereotactic ablation trials, followed by modern imaging-guided RF ablation series for mesial temporal lobe epilepsy. The developments of LITT and MRI thermometry are then discussed. Finally, the two currently available MRI-guided LITT systems are reviewed for their role in the treatment of mesial temporal lobe and other medically refractory epilepsies.
Author Notes
Keywords
Research Categories
  • Health Sciences, Medicine and Surgery
  • Biology, Neuroscience

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