Correlation between apparent diffusion coefficients and HER2 status in gastric cancers: pilot study.

• Type of Material: Article
• Authors: Jian He, The Affiliated Hospital of Nanjing University Medical School; Hua Shi, The Affiliated Hospital of Nanjing University Medical School; Zhuping Zhou, The Affiliated Hospital of Nanjing University Medical School; Jun Chen, The Affiliated Hospital of Nanjing University Medical School; Wenxian Guan, The Affiliated Hospital of Nanjing University Medical School; Hao Wang, The Affiliated Hospital of Nanjing University Medical School; Haiping Yu, The Affiliated Hospital of Nanjing University Medical School; Song Liu, The Affiliated Hospital of Nanjing University Medical School; Zhengyang Zhou, The Affiliated Hospital of Nanjing University Medical School; Xiaofeng Yang, Emory University; Tian Liu, Emory University
• Language: English
• Date: 2015-10-20
• Publisher: BioMed Central
• Publication Version: Final Published Version
• Copyright Statement: © He et al. 2015
• License: Creative Commons Attribution 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1186/s12885-015-1726-7
• Title of Journal or Parent Work: BMC Cancer
• ISSN: 1471-2407
• Volume: 15
• Issue: 1
• Start Page: 749
• End Page: 749
• Grant/Funding Information: his work was supported by grants from National Natural Science Foundation of China (IP: 81371516, 81501441), Foundation of National Health and Family Planning Commission of China (IP: W201306), Nature Science Foundation of Jiangsu Province (IP: BK2012531, BK20150109), Nanjing City Young Health Personnel Training Project (third level) (ID: QRX11178) and Jiangsu Province Health and Family Planning Commission Youth Scientific Research Project (ID: Q201508).
• Keywords: erbB-2; Immunohistochemistry; Diffusion magnetic resonance imaging; Receptor; Stomach neoplasms; Molecular targeted therapy
• Research Categories: Health Sciences, Immunology; Health Sciences, Oncology; Health Sciences, Pathology

Abstract

BACKGROUND: To evaluate whether apparent diffusion coefficient (ADC) value of gastric cancer obtained from diffusion weighted imaging (DWI) correlates with the HER2 status. METHODS: Forty-five patients, who had been diagnosed with gastric cancer through biopsy, were enrolled in this IRB-approved study. Each patient underwent a DWI (b values: 0 and 1,000 sec/mm(2)) prior to surgery (curative gastrectomy or palliative resection). Postoperative microscopic findings, HER2 status by immunohistochemical analysis and fluorescence in situ hybridization (FISH) were obtained. HER2 status was compared among gastric cancers with various histopathological features using the chi square test. The ADC values of gastric cancers with positive and negative HER2 were compared using the student t test. RESULTS: A weak yet significant correlation was observed between the mean ADC values and HER2 status (r = 0.312, P = 0.037) and scores (r = 0.419, P = 0.004). The mean ADC value of HER2-positive gastric cancers was significantly higher than those of HER2-negative tumors (1.211 vs. 0.984 mm(2)/s, P = 0.020). The minimal ADC value of HER2-positive gastric cancers was significantly higher than those of HER2-negative tumors (1.105 vs. 0.905 × 10(-3) mm(2)/s, P = 0.036). CONCLUSIONS: In this pilot study, we have demonstrated that the ADC values of gastric cancer correlate with the HER2 status. Future research is warranted to see if DWI can predict HER2 status and help in tailoring therapy for gastric cancer.